Cris dos Remedios; a Driving Force in Muscle Research
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical Reviews"
DOI: 10.1007/s12551-020-00704-6
Abstract: I first met Cris in the mid ‘70s when he came to King’s College London, Biophysics Department, Drury Lane on a sabbatical to work with the muscle group on actin. He came with an interest… read more here.
Keywords: cris; heart; muscle; intercalated disc ... See more keywords
Flotillins in the intercalated disc are potential modulators of cardiac excitability.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.11.007
Abstract: BACKGROUND The intercalated disc (ID) is important for cardiac remodeling and has become a subject of intensive research efforts. However, as yet the composition of the ID has still not been conclusively resolved and the… read more here.
Keywords: flotillin flotillin; flotillin; flotillins intercalated; intercalated disc ... See more keywords
Microtubule plus-end tracking proteins: novel modulators of cardiac sodium channels and arrhythmogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular research"
DOI: 10.1093/cvr/cvad052
Abstract: The cardiac sodium channel NaV1.5 is an essential modulator of cardiac excitability, with decreased NaV1.5 levels at the plasma membrane and consequent reduction in sodium current (INa) leading to potentially lethal cardiac arrhythmias. NaV1.5 is… read more here.
Keywords: intercalated disc; sodium; interacting proteins; membrane ... See more keywords
The Function of Llgl1 in mediating intercalated disc composition and cardiomyocyte proliferation
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733890
Abstract: Introduction: The loss of functional cardiomyocytes (CMs) coupled with the limited regenerative capacity of the adult heart leads to the development of systolic heart failure. Thus, there is a great interest in exploring novel therapeutics… read more here.
Keywords: intercalated disc; llgl1; proliferation; development ... See more keywords
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2023 at "Physiological reviews"
DOI: 10.1152/physrev.00021.2022
Abstract: The intercalated disc (ID) is a highly specialized structure, connecting cardiomyocytes via mechanical and electrical junctions. Although described in some detail by light microscopy in the 19th century, it was in 1966 that electron microscopy… read more here.
Keywords: unique organelle; intercalated disc; microscopy; synchrony ... See more keywords