Systematic Search for Blood-Brain Barrier Modulating Peptides Based on Exhaustive E-Cadherin Domain-Domain Docking
Sign Up to like & getrecommendations! Published in 2025 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.5c01227
Abstract: E- and VE-cadherins are among proteins forming intercellular junctions that are a crucial component of cell-cell adhesion in the intercellular junctions of the biological barriers (i.e., blood-brain barrier (BBB) and intestinal mucosa barrier). The BBB… read more here.
Keywords: brain; intercellular junctions; barrier; cadherin ... See more keywords
Ca2+signaling machinery is present at intercellular junctions and structures associated with junction turnover in rat Sertoli cellsâ€
Sign Up to like & getrecommendations! Published in 2017 at "Biology of Reproduction"
DOI: 10.1093/biolre/iox042
Abstract: Abstract The endoplasmic reticulum (ER) in Sertoli cells is a component of unique adhesion junctions (ectoplasmic specializations—ESs) and is closely associated with structures termed tubulobulbar complexes (TBCs) that internalize intercellular junctions during sperm release and… read more here.
Keywords: machinery; intercellular junctions; junction turnover; sertoli cells ... See more keywords
Piezo1 balances membrane and cortex tension to stabilize intercellular junctions and maintain the epithelial barrier
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cell Science"
DOI: 10.1242/jcs.263938
Abstract: ABSTRACT Formation of the skin barrier is essential for organismal survival and tissue homeostasis. Barrier formation requires positioning of functional tight junctions (TJs) to the most suprabasal viable layer of the epidermis through a mechanical… read more here.
Keywords: intercellular junctions; piezo1 balances; barrier; piezo1 ... See more keywords
Treponema pallidum Disrupts VE-Cadherin Intercellular Junctions and Traverses Endothelial Barriers Using a Cholesterol-Dependent Mechanism
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.691731
Abstract: Treponema pallidum subspecies pallidum, the causative agent of syphilis, traverses the vascular endothelium to gain access to underlying tissue sites. Herein, we investigate the mechanisms associated with T. pallidum traversal of endothelial barriers. Immunofluorescence microscopy… read more here.
Keywords: treponema pallidum; intercellular junctions; cholesterol dependent; traverses endothelial ... See more keywords