A Combination Therapy Using Electrical Stimulation and Adaptive, Conductive Hydrogels Loaded with Self‐Assembled Nanogels Incorporating Short Interfering RNA Promotes the Repair of Diabetic Chronic Wounds
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201425
Abstract: In addition to oxidative stress and impaired angiogenesis, the overexpression of metalloproteinases (MMPs) and proinflammatory cytokines, which are promoted by hyperglycemia, causes chronic inflammation in diabetic wounds. Herein, TA‐siRNA nanogels are prepared for the first… read more here.
Keywords: adaptive conductive; electrical stimulation; interfering rna; therapy using ... See more keywords
Computational Identification of Small Interfering RNA Targets in SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Virologica Sinica"
DOI: 10.1007/s12250-020-00221-6
Abstract: With the epidemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) worldwide and in the absence of any effective vaccine, there is an urgent need to find a specific anti- SARS-CoV-2 agent. In this study,… read more here.
Keywords: small interfering; identification small; interfering rna; rna targets ... See more keywords
Characterization of an adulticidal and larvicidal interfering RNA pesticide that targets a conserved sequence in mosquito G protein-coupled dopamine 1 receptor genes.
Sign Up to like & getrecommendations! Published in 2020 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2020.103359
Abstract: G protein-coupled receptors (GPCRs), key regulators of a variety of critical biological processes, are attractive targets for insecticide development. Given the importance of these receptors in many organisms, including humans, it is critical that novel… read more here.
Keywords: mosquito; protein coupled; interfering rna; rna pesticide ... See more keywords
Organometallic dendrimers based on Ruthenium(II) N-heterocyclic carbenes and their implication as delivery systems of anticancer small interfering RNA.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111540
Abstract: With the purpose of obtaining a new dendritic system against cancer, this paper is focused on the synthesis of spherical carbosilane metallodendrimers of different generations holding Ru(II) N-heterocyclic carbene (NHC) on the periphery from the… read more here.
Keywords: anticancer small; ruthenium; organometallic dendrimers; small interfering ... See more keywords
Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00297-x
Abstract: Human endothelial cells are initiators and targets of the rejection response. Pre-operative modification of endothelial cells by small interfering RNA transfection could shape the nature of the host response post-transplantation. Ablation of endothelial cell class… read more here.
Keywords: class; small interfering; transplantation; endothelial cells ... See more keywords
Viral infection impacts transposable element transcript amounts in Drosophila
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2006106117
Abstract: Significance Transposable elements (TEs) are genomic parasites that are found in all genomes. Here, we show that viral infections impact TE transcript amounts in Drosophila somatic tissues. This is of major importance in the understanding… read more here.
Keywords: transcript amounts; small interfering; viral infections; impacts transposable ... See more keywords
Small interfering RNA-based nanotherapeutics for treating skin-related diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on drug delivery"
DOI: 10.1080/17425247.2023.2206646
Abstract: INTRODUCTION RNA interference (RNAi) has demonstrated great potential in treating skin-related diseases, as small interfering RNA (siRNA) can efficiently silence specific genes. The design of skin delivery systems for siRNA is important to protect the… read more here.
Keywords: skin related; skin; small interfering; interfering rna ... See more keywords
Sugar-Baited Delivery of Small Interfering RNA for Gene Silencing in Adult Mosquitoes.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot107808
Abstract: RNA interference (RNAi), an innate regulatory mechanism that is conserved across many eukaryotic species, has been harnessed for experimental gene silencing in many organisms, including mosquitoes. This protocol describes an optimized method for inducing RNAi… read more here.
Keywords: adult; small interfering; gene silencing; interfering rna ... See more keywords
Switching the intracellular pathway and enhancing the therapeutic efficacy of small interfering RNA by auroliposome
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DOI: 10.1126/sciadv.aba5379
Abstract: Auroliposome represents a highly effective siRNA delivery platform for in vitro and in vivo application. Gene silencing using small-interfering RNA (siRNA) is a viable therapeutic approach; however, the lack of effective delivery systems limits its… read more here.
Keywords: delivery; small interfering; efficacy; interfering rna ... See more keywords
Single-chain antibody–delivered Livin siRNA inhibits human malignant melanoma growth in vitro and in vivo
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DOI: 10.1177/1010428317701645
Abstract: Although gene therapy has brought new insights into the treatment of malignant melanoma, targeting delivery of nucleic acid which targets critical oncogene/anti-oncogene in vivo is still a bottleneck in the therapeutic application. Our previous in… read more here.
Keywords: melanoma; chain antibody; small interfering; interfering rna ... See more keywords
Short Hairpin RNAs for Strand-Specific Small Interfering RNA Production
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00940
Abstract: RNA interference (RNAi) is an effective mechanism for inhibiting gene expression at the post-transcriptional level. Expression of a messenger RNA (mRNA) can be inhibited by a ∼22-nucleotide (nt) small interfering (si)RNA with the corresponding reverse… read more here.
Keywords: small interfering; rna; hairpin; strand ... See more keywords