Inhibition of dengue virus infection by small interfering RNAs that target highly conserved sequences in the NS4B or NS5 coding regions
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3757-2
Abstract: Dengue fever is one of the most common viral infections in the world. Although a vaccine against dengue virus (DENV) has been approved in several countries, this disease is still considered a public health priority… read more here.
Keywords: dengue virus; small interfering; sequences ns4b; conserved sequences ... See more keywords
Computational design of small interfering RNAs and small hairpin RNAs to silence mutated P53 gene expressions
Sign Up to like & getrecommendations! Published in 2018 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2018.04.004
Abstract: Abstract RNA silencing is a novel gene regulatory mechanism that confines the transcript level by either preventing translation or by the initiation of particular RNA degradation. Small interfering RNAs are regularly represented as the exogenously… read more here.
Keywords: small interfering; p53 gene; small hairpin; interfering rnas ... See more keywords
Amide-Modified RNA: Using Protein Backbone to Modulate Function of Short Interfering RNAs.
Sign Up to like & getrecommendations! Published in 2020 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.0c00249
Abstract: ConspectusRNA-based technologies to control gene expression, such as RNA interference (RNAi) and CRISPR-Cas9, have become powerful tools in molecular biology and genomics. The exciting potential that RNAi and CRISPR-Cas9 may also become new therapeutic approaches… read more here.
Keywords: short interfering; rnai; amide linkages; backbone ... See more keywords
Redistribution of CHH Methylation and Small Interfering RNAs across the Genome of Tomato ddm1 Mutants
Sign Up to like & getrecommendations! Published in 2018 at "Plant Cell"
DOI: 10.1105/tpc.18.00167
Abstract: The production of siRNAs and the CHH methylation mediated by the RdDM pathway are enhanced in heterochromatin when DDM1 is nonfunctional, at the expense of silencing mechanisms occurring in euchromatin. In plants, cytosine methylation, an… read more here.
Keywords: methylation; chh methylation; ddm1; tomato ... See more keywords
Biogenesis and regulatory hierarchy of phased small interfering RNAs in plants
Sign Up to like & getrecommendations! Published in 2018 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.12882
Abstract: Summary Several varieties of small RNAs including microRNAs (miRNAs) and small interfering RNAs (siRNAs) are generated in plants to regulate development, genome stability and response to adverse environments. Phased siRNA (phasiRNA) is a type of… read more here.
Keywords: hierarchy phased; small interfering; phased small; biogenesis regulatory ... See more keywords
Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "EMBO reports"
DOI: 10.15252/embr.201745336
Abstract: Trinucleotide repeat (TNR) expansions in the genome cause a number of degenerative diseases. A prominent TNR expansion involves the triplet CAG in the huntingtin (HTT) gene responsible for Huntington's disease (HD). Pathology is caused by… read more here.
Keywords: toxic cancer; rnas based; small interfering; cancer cells ... See more keywords
Potential of siRNA in COVID-19 therapy: Emphasis on in silico design and nanoparticles based delivery
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1112755
Abstract: Small interfering RNA (siRNA)-mediated mRNA degradation approach have imparted its eminence against several difficult-to-treat genetic disorders and other allied diseases. Viral outbreaks and resulting pandemics have repeatedly threatened public health and questioned human preparedness at… read more here.
Keywords: silico design; small interfering; interfering rna; interfering rnas ... See more keywords
Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25081877
Abstract: Cholesterol derivatives of nuclease-resistant, anti-MDR1 small-interfering RNAs were designed to contain a 2’-OMe-modified 21-bp siRNA and a 63-bp TsiRNA in order to investigate their accumulation and silencing activity in vitro and in vivo. The results… read more here.
Keywords: accumulation; silencing activity; small interfering; cholesterol ... See more keywords
Small interfering RNAs based therapies for intracerebral hemorrhage: challenges and progress in drug delivery systems
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.332129
Abstract: Intracerebral hemorrhage (ICH) is a subtype of stroke associated with higher rates of mortality. Currently, no effective drug treatment is available for ICH. The molecular pathways following ICH are complicated and diverse. Nucleic acid therapeutics… read more here.
Keywords: small interfering; interfering rnas; drug; delivery ... See more keywords