MEK/ERK MAP kinase limits poly I:C-induced antiviral gene expression in RAW264.7 macrophages by reducing interferon-beta expression.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS letters"
DOI: 10.1002/1873-3468.14200
Abstract: Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (or the synthetic dsRNA analog poly I:C) and induces a signal transduction pathway that results in activation of transcription factors that induce expression of antiviral genes including… read more here.
Keywords: mek erk; antiviral gene; interferon; gene expression ... See more keywords
Safety, Tolerability, and Pharmacokinetics of PF‐06823859, an Anti–Interferon β Monoclonal Antibody: A Randomized, Phase I, Single‐ and Multiple‐Ascending‐Dose Study
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.887
Abstract: This double‐blind, randomized, placebo‐controlled, dose‐ascending, first‐in‐human study (NCT02766621) assessed the safety, tolerability, and pharmacokinetics (PK) of PF‐06823859, an anti–interferon β monoclonal antibody. Healthy subjects were randomized to single ascending doses (SADs) of intravenous PF‐06823859 30,… read more here.
Keywords: placebo; safety tolerability; tolerability pharmacokinetics; interferon ... See more keywords
Type‐I Interferon assessment in 45 minutes using the FilmArray® PCR platform in SARS‐CoV‐2 and other viral infections
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048978
Abstract: Low concentrations of type‐I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID‐19). However, following the type‐I interferon response (IR) in early stage disease is a major… read more here.
Keywords: type interferon; using filmarray; interferon; minutes using ... See more keywords
Revisiting the Paradox of Interferon‐Stimulated Gene Expression as a Predictor of Hepatitis C Virus Treatment Response, a Decade Later
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DOI: 10.1002/hep.30195
Abstract: Endogenous interferon signaling is the body's first line of defense against viruses, providing the rationale for use of IFN as the backbone of treatment for viral hepatitis for over two decades. Hepatitis C viral RNA… read more here.
Keywords: paradox interferon; revisiting paradox; hepatitis; treatment ... See more keywords
The Role of Type I Interferon in the Treatment of COVID-19.
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DOI: 10.1002/jmv.27317
Abstract: Although significant research was done to find effective drugs against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), no definite effective drug exists. Thus the research is now shifted towards… read more here.
Keywords: covid; treatment; interferon; role type ... See more keywords
Evolution and emergence of primate‐specific interferon regulatory factor 9
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28521
Abstract: The binding of interferon (IFN) to its receptors leads to formation of IFN‐stimulated gene factor 3 (ISGF3) complex that activates the transcription of cellular IFN‐regulated genes. IFN regulatory factor 9 (IRF9, also called ISGF3γ or… read more here.
Keywords: canonical irf9; primate specific; irf9; regulatory factor ... See more keywords
Omicron‐induced interferon signaling prevents influenza A H1N1 and H5N1 virus infection
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DOI: 10.1002/jmv.28686
Abstract: Recent findings in permanent cell lines suggested that SARS‐CoV‐2 Omicron BA.1 induces a stronger interferon response than Delta. Here, we show that BA.1 and BA.5 but not Delta induce an antiviral state in air‐liquid interface… read more here.
Keywords: virus infection; infection; omicron induced; induced interferon ... See more keywords
Intratumoral Delivery of Interferonγ‐Secreting Mesenchymal Stromal Cells Repolarizes Tumor‐Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo
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DOI: 10.1002/stem.2801
Abstract: Neuroblastoma, the most common extracranial solid tumor in childhood, remains a therapeutic challenge. However, one promising patient treatment strategy is the delivery of anti‐tumor therapeutic agents via mesenchymal stromal cell (MSC) therapy. MSCs have been… read more here.
Keywords: intratumoral delivery; mesenchymal stromal; interferon; proliferation ... See more keywords
Roles of Arenavirus Z Protein in Mediating Virion Budding, Viral Transcription-Inhibition and Interferon-Beta Suppression.
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DOI: 10.1007/978-1-4939-6981-4_16
Abstract: The smallest arenaviral protein is the zinc-finger protein (Z) that belongs to the RING finger protein family. Z serves as a main component required for virus budding from the membrane of the infected cells through… read more here.
Keywords: suppression; inhibition; interferon; roles arenavirus ... See more keywords
The role of interferon-γ in cardiovascular disease: an update
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation Research"
DOI: 10.1007/s00011-020-01382-6
Abstract: Cardiovascular disease (CVD) is the leading cause of death, globally, and its prevalence is only expected to rise due to the increasing incidence of co-morbidities such as obesity and diabetes. Medical treatment of CVD is… read more here.
Keywords: ifn; interferon; role; cvd ... See more keywords
Efficacy of fingolimod after switching from interferon β-1a in an adolescent with multiple sclerosis: case report
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DOI: 10.1007/s10072-021-05170-w
Abstract: Pediatric-onset multiple sclerosis (POMS) accounts for approximately 2–10% of all cases of multiple sclerosis (MS) and is associated with higher levels of disease activity than adult-onset MS, including higher rates of clinical relapse and a… read more here.
Keywords: sclerosis; line; interferon; case ... See more keywords