Intravesical Interferon Therapy vs Hyaluronic Acid for Pain Among Female Individuals With Interstitial Cystitis
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.4880
Abstract: Key Points Question Does intravesical interferon instillation offer a novel treatment option for female patients with interstitial cystitis (IC)? Findings In a randomized clinical trial of 52 patients with IC, intravesical interferon treatment led to… read more here.
Keywords: interstitial cystitis; pain; interferon; hyaluronic acid ... See more keywords
MEK/ERK MAP kinase limits poly I:C-induced antiviral gene expression in RAW264.7 macrophages by reducing interferon-beta expression.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS letters"
DOI: 10.1002/1873-3468.14200
Abstract: Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (or the synthetic dsRNA analog poly I:C) and induces a signal transduction pathway that results in activation of transcription factors that induce expression of antiviral genes including… read more here.
Keywords: mek erk; antiviral gene; interferon; gene expression ... See more keywords
Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder
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DOI: 10.1002/advs.202500942
Abstract: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease characterized by anti‐aquaporin 4 (AQP4) antibody‐mediated astrocyte damage and subsequent demyelination. Prior attempts to treat NMOSD with interferon‐beta (IFN‐β), a disease‐modifying therapy for multiple sclerosis, resulted… read more here.
Keywords: optica spectrum; neuromyelitis optica; interferon; spectrum disorder ... See more keywords
Computational Design and Glycoengineering of Interferon-Lambda for Nasal Prophylaxis Against Respiratory Viruses.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202506764
Abstract: Interferon-λ (IFN-λ), a type III interferon that selectively targets epithelial cells, holds strong potential as an intranasal antiviral due to its ability to suppress respiratory virus replication without inducing systemic inflammation. However, clinical translation of… read more here.
Keywords: design glycoengineering; nasal; computational design; interferon ... See more keywords
Safety, Tolerability, and Pharmacokinetics of PF‐06823859, an Anti–Interferon β Monoclonal Antibody: A Randomized, Phase I, Single‐ and Multiple‐Ascending‐Dose Study
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.887
Abstract: This double‐blind, randomized, placebo‐controlled, dose‐ascending, first‐in‐human study (NCT02766621) assessed the safety, tolerability, and pharmacokinetics (PK) of PF‐06823859, an anti–interferon β monoclonal antibody. Healthy subjects were randomized to single ascending doses (SADs) of intravenous PF‐06823859 30,… read more here.
Keywords: placebo; safety tolerability; tolerability pharmacokinetics; interferon ... See more keywords
PARP7i Clinical Candidate RBN‐2397 Exerts Antiviral Activity by Modulating Interferon‐β Associated Innate Immune Response in Macrophages
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.70013
Abstract: Polyadenosine diphosphate‐ribose polymerase 7 (PARP7) acts as a suppressor of the type I interferon (IFN) signaling pathway via suppressing TANK‐binding protein 1 (TBK1). Research study indicates that inhibition of PARP7 could potentially regulate tumor immunity.… read more here.
Keywords: candidate rbn; interferon; clinical candidate; rbn 2397 ... See more keywords
Type‐I Interferon assessment in 45 minutes using the FilmArray® PCR platform in SARS‐CoV‐2 and other viral infections
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048978
Abstract: Low concentrations of type‐I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID‐19). However, following the type‐I interferon response (IR) in early stage disease is a major… read more here.
Keywords: type interferon; using filmarray; interferon; minutes using ... See more keywords
Revisiting the Paradox of Interferon‐Stimulated Gene Expression as a Predictor of Hepatitis C Virus Treatment Response, a Decade Later
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30195
Abstract: Endogenous interferon signaling is the body's first line of defense against viruses, providing the rationale for use of IFN as the backbone of treatment for viral hepatitis for over two decades. Hepatitis C viral RNA… read more here.
Keywords: paradox interferon; revisiting paradox; hepatitis; treatment ... See more keywords
The Role of Type I Interferon in the Treatment of COVID-19.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27317
Abstract: Although significant research was done to find effective drugs against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), no definite effective drug exists. Thus the research is now shifted towards… read more here.
Keywords: covid; treatment; interferon; role type ... See more keywords
Evolution and emergence of primate‐specific interferon regulatory factor 9
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28521
Abstract: The binding of interferon (IFN) to its receptors leads to formation of IFN‐stimulated gene factor 3 (ISGF3) complex that activates the transcription of cellular IFN‐regulated genes. IFN regulatory factor 9 (IRF9, also called ISGF3γ or… read more here.
Keywords: canonical irf9; primate specific; irf9; regulatory factor ... See more keywords
Omicron‐induced interferon signaling prevents influenza A H1N1 and H5N1 virus infection
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28686
Abstract: Recent findings in permanent cell lines suggested that SARS‐CoV‐2 Omicron BA.1 induces a stronger interferon response than Delta. Here, we show that BA.1 and BA.5 but not Delta induce an antiviral state in air‐liquid interface… read more here.
Keywords: virus infection; infection; omicron induced; induced interferon ... See more keywords