Refractory nontuberculous mycobacterial infection and potential hidden immunodeficiency related to RAG mutation and production of anti-interferon-α autoantibodies: a case report
Sign Up to like & getrecommendations! Published in 2025 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-025-10975-7
Abstract: Nontuberculous mycobacterial infectious diseases are associated with host immunological status. Neutralizing anti-interferon (IFN)-γ autoantibodies have been considered as a significant cause of nontuberculous mycobacterial infections. However, another autoantibody specifically targeting interferon-α, occurring in patients with… read more here.
Keywords: anti interferon; mycobacterial infection; nontuberculous mycobacterial; interferon autoantibodies ... See more keywords
Talaromyces marneffei and Burkholderia cepacia Co-Infection in a HIV-Uninfected Patient with Anti-Interferon-γ Autoantibodies
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DOI: 10.2147/idr.s312042
Abstract: Abstract A high titer of neutralizing anti-interferon-γ autoantibodies can cause immunodeficiency associated with severe or disseminated infections caused by Talaromyces marneffei in human immunodeficiency virus-negative patients. Herein, we reported a rare case of disseminated Talaromyces… read more here.
Keywords: patient; interferon autoantibodies; talaromyces marneffei; marneffei burkholderia ... See more keywords
Interferon autoantibodies as signals of a sick thymus
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1327784
Abstract: Type I interferons (IFN-I) are key immune messenger molecules that play an important role in viral defense. They act as a bridge between microbe sensing, immune function magnitude, and adaptive immunity to fight infections, and… read more here.
Keywords: sick thymus; signals sick; autoantibodies signals; interferon autoantibodies ... See more keywords