Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants to Guide Therapeutic Dosing
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DOI: 10.1002/cpdd.784
Abstract: BMS‐986184 is a human, second‐generation, anti–interferon‐γ–induced protein 10 (IP‐10) monoclonal antibody. In this study the pharmacokinetics and target engagement (TE) of BMS‐986184 in healthy participants were characterized using population‐based target‐mediated drug disposition (TMDD) modeling and… read more here.
Keywords: bms 986184; healthy participants; interferon induced; pharmacokinetics target ... See more keywords
Interferon‐Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection
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DOI: 10.1002/hep.30699
Abstract: Although adaptive immune responses against hepatitis C virus (HCV) infection have been studied in great detail, the role of innate immunity in protection against HCV infection and immune evasion is only partially understood. Interferon‐induced transmembrane… read more here.
Keywords: evasion; interferon induced; infection; hcv ... See more keywords
Interferon‐induced transmembrane protein 1‐mediated EGFR/SOX2 signaling axis is essential for progression of non‐small cell lung cancer
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DOI: 10.1002/ijc.31926
Abstract: Emerging data indicate that interferon‐induced transmembrane protein 1 (IFITM1) plays an important role in many cancers. However, it remains unclear whether IFITM1 is functionally indispensable in nonsmall cell lung cancer (NSCLC). Here, using NSCLC cell… read more here.
Keywords: interferon induced; ifitm1; induced transmembrane; sox2 ... See more keywords
Immune responses, subcellular localization, and antiviral activity of interferon-induced protein 35 (IFP35) in rock bream (Oplegnathus fasciatus).
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104142
Abstract: Interferon-induced protein 35 kDa (IFP35) has been demonstrated to play important roles in antiviral defense, inflammatory response and cancer progression. However, its precise function in teleost fish remains to be elucidated. Herein, we functionally characterized… read more here.
Keywords: interferon induced; ifp35; rock bream;
Elevated serum interferon γ-induced protein 10 kDa is associated with TAFRO syndrome
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DOI: 10.1038/srep42316
Abstract: Multicentric Castleman disease (MCD) is a heterogeneous lymphoproliferative disorder. It is characterized by inflammatory symptoms, and interleukin (IL)-6 contributes to the disease pathogenesis. Human herpesvirus 8 (HHV-8) often drives hypercytokinemia in MCD, although the etiology… read more here.
Keywords: imcd; interferon induced; induced protein; tafro imcd ... See more keywords
Interferon-Induced Protein With Multiple Tetratricopeptide Repeats 3 Is Associated With Response to Chemotherapy and Recurrence but Not With Survival.
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DOI: 10.1097/mpa.0000000000001691
Abstract: OBJECTIVES The interferon-induced protein with multiple tetratricopeptide repeats 3 (IFIT3) seems to be associated with the prognosis in pancreatic cancer. Here we clarify whether the heterogeneity of IFIT3 expression affects previous IFIT3 analysis. METHODS This… read more here.
Keywords: chemotherapy; interferon induced; induced protein; ifit3 ... See more keywords
Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi’s Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner
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DOI: 10.1128/mbio.02113-21
Abstract: IFITM proteins are the first line of defense against infection by many pathogens and may also have therapeutic importance, as they, among other effectors, mediate the antiviral effect of interferons. Neither their function against herpesviruses… read more here.
Keywords: induced transmembrane; kshv rrv; interferon induced; infection ... See more keywords
Role of interferon-induced GTPases in leishmaniasis
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DOI: 10.1371/journal.pntd.0010093
Abstract: Leishmaniasis continues to be a major health problem worldwide. The efficacy of reported vaccines is poor, and there is no safe and cost-effective treatment, partly because the mechanisms of the disease are not fully understood.… read more here.
Keywords: gtpases leishmaniasis; induced gtpases; role; interferon induced ... See more keywords
Viral infection triggers interferon-induced expulsion of live Cryptococcus neoformans by macrophages
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DOI: 10.1371/journal.ppat.1008240
Abstract: Cryptococcus neoformans is an opportunistic human pathogen, which causes serious disease in immunocompromised hosts. Infection with this pathogen is particularly relevant in HIV+ patients, where it leads to around 200,000 deaths per annum. A key… read more here.
Keywords: cryptococcus neoformans; triggers interferon; interferon induced; infection triggers ... See more keywords
Increased Interferon-Induced Protein With Tetracopeptides (IFITs) Reduces Mycobacterial Growth
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DOI: 10.3389/fcimb.2022.828439
Abstract: Objectives The host immune response towards Mycobacterium tuberculosis (M. tb) is known to vary with the virulence of mycobacterial species. While the majority of M. tb-exposed individuals develop latent TB infection (LTBI), a small proportion… read more here.
Keywords: response; interferon induced; expression; tetracopeptides ifits ... See more keywords
The Interferon-Induced Transmembrane Protein 3 -rs12252 Allele May Predict COVID-19 Severity Among Ethnic Minorities
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DOI: 10.3389/fgene.2021.692254
Abstract: The COVID-19 pandemic has infected 176million people and caused 3.8million deaths worldwide. Artificial intelligence applications and Genome Wide Association Studies (GWAS) have helped us better understand factors that predict COVID-19 severity (The Severe Covid-19 GWAS… read more here.
Keywords: interferon induced; among ethnic; severity; predict covid ... See more keywords