IFNL4: Notable Variants and Associated Phenotypes.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144289
Abstract: Interferon lambda proteins activate the JAK-STAT signalling pathway, resulting in upregulation of genes with antiviral effects. The interferon lambda family was initially thought to be redundant to the interferon alpha family, which signals through the… read more here.
Keywords: associated phenotypes; ifnl4; ifnl4 notable; notable variants ... See more keywords
Interferon lambda as a potential treatment for COVID-19
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DOI: 10.1080/14712598.2023.2211709
Abstract: ABSTRACT Introduction Pegylated interferon lambda substantially reduced the risk of COVID-19-related hospitalizations or emergency room visits in a recent phase 3, multi-center, randomized, double-blind, placebo-controlled study of high-risk, non-hospitalized adult patients with SARS-CoV-2 infection compared… read more here.
Keywords: lambda potential; interferon lambda; treatment covid; interferon ... See more keywords
Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner
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DOI: 10.1128/mbio.03857-21
Abstract: Pregnancy is an immunologically complex situation, which must balance protecting the fetus from maternal pathogens with preventing maternal immune rejection of non-self fetal and placental tissue. Cytokines, such as interferon lambda (IFN-λ), contribute to antiviral… read more here.
Keywords: interferon lambda; maternal fetal; pathology; ifn ... See more keywords
The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients
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DOI: 10.1186/s12985-021-01692-z
Abstract: Background The recent pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has elevated several clinical and scientific questions. These include how host genetic factors influence the pathogenesis and disease susceptibility. Therefore, the aim of… read more here.
Keywords: nucleotide polymorphisms; single nucleotide; covid; covid infection ... See more keywords
Characterising the effects of interferon lambda on dendritic cell function and activation
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DOI: 10.26180/5e1071174ea41
Abstract: This PhD has focused on an anti-viral protein known as Interferon-Lambda. This protein is important for fighting viruses at mucosal sites of the body such as in the lung and gastrointestinal tract and we have… read more here.
Keywords: effects interferon; lambda dendritic; cell function; characterising effects ... See more keywords
Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections
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DOI: 10.3389/fimmu.2017.00749
Abstract: Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses… read more here.
Keywords: potent regulator; viral infections; regulator intestinal; intestinal viruses ... See more keywords
Bovine Interferon Lambda Is a Potent Antiviral Against SARS-CoV-2 Infection in vitro
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DOI: 10.3389/fvets.2020.603622
Abstract: Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces. This localized activity results in reduced toxicity compared to… read more here.
Keywords: sars cov; cov infection; ifn; interferon lambda ... See more keywords
Interferon lambda 4 impacts the genetic diversity of hepatitis C virus
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DOI: 10.7554/elife.42463
Abstract: Hepatitis C virus (HCV) is a highly variable pathogen that frequently establishes chronic infection. This genetic variability is affected by the adaptive immune response but the contribution of other host factors is unclear. Here, we… read more here.
Keywords: interferon lambda; hepatitis virus;
Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium
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DOI: 10.7554/elife.74072
Abstract: Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that bacterial microbiota stimulate a homeostatic ISG signature in the intestine of specific pathogen-free… read more here.
Keywords: interferon lambda; bacterial microbiota; microbiota; intestinal epithelium ... See more keywords