Mechanisms of impairment of interferon production by SARS-CoV-2.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20221037
Abstract: Interferons (IFNs) are crucial components of the cellular innate immune response to viral infections. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a remarkable capacity to suppress the host IFN production to benefit… read more here.
Keywords: production sars; mechanisms impairment; impairment interferon; interferon production ... See more keywords
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204539119
Abstract: Viruses evade the innate immune response by suppressing the production or activity of cytokines such as type I interferons (IFNs). Here we report the discovery of a novel mechanism by which the SARS-CoV-2 virus co-opts… read more here.
Keywords: translation; impairs interferon; interferon production; production ... See more keywords
Mathematical Modeling Finds Disparate Interferon Production Rates Drive Strain-Specific Immunodynamics during Deadly Influenza Infection
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DOI: 10.3390/v14050906
Abstract: The timing and magnitude of the immune response (i.e., the immunodynamics) associated with the early innate immune response to viral infection display distinct trends across influenza A virus subtypes in vivo. Evidence shows that the… read more here.
Keywords: interferon production; specific immunodynamics; strain specific; infection ... See more keywords
Reactive oxygen species oxidize STING and suppress interferon production
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DOI: 10.7554/elife.57837
Abstract: Reactive oxygen species (ROS) are by-products of cellular respiration that can promote oxidative stress and damage cellular proteins and lipids. One canonical role of ROS is to defend the cell against invading bacterial and viral… read more here.
Keywords: interferon production; reactive oxygen; oxygen species; interferon ... See more keywords