Hepatic Interferon Regulatory Factor 6 Alleviates Liver Steatosis and Metabolic Disorder by Transcriptionally Suppressing Peroxisome Proliferator‐Activated Receptor γ in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30559
Abstract: Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and growing unmet therapeutic need has inspired numerous studies in the field. Integrating the published genomic data available in the Gene Expression Omnibus… read more here.
Keywords: interferon regulatory; regulatory factor; irf6; mice ... See more keywords
Dissecting the impact of bromodomain inhibitors on the Interferon Regulatory Factor 4‐MYC oncogenic axis in multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3016
Abstract: B‐cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the pathogenesis and progression of multiple myeloma (MM), a currently incurable plasma cell malignancy. Aberrant expression of IRF4 and the establishment of… read more here.
Keywords: irf4; cell; myc; interferon regulatory ... See more keywords
Association of interferon regulatory factor 5 (IRF5) gene polymorphisms with juvenile idiopathic arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Rheumatology"
DOI: 10.1007/s10067-018-4010-9
Abstract: Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an… read more here.
Keywords: irf5; jia; factor irf5; interferon regulatory ... See more keywords
A rapid method for solubilization of chimeric human interferon regulatory factor-1 (IRF-1) protein in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06260-w
Abstract: Interferon regulatory factor-1 (IRF-1) is a vertebrate transcription factor that plays significant roles in cell cycle regulation, anti-viral response, tumor suppression and immune response. High-level expression of recombinant IRF-1 at 37 °C leads to the formation… read more here.
Keywords: irf; interferon regulatory; factor irf; regulatory factor ... See more keywords
Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108345
Abstract: Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most… read more here.
Keywords: response; interferon regulatory; expression bats; interferon ... See more keywords
Genetic variants of interferon regulatory factor 5 associated with the risk of community-acquired pneumonia.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.08.080
Abstract: Interferon regulatory factor 5 (IRF5) is a key transcription factor involved in the control of the expression of pro-inflammatory cytokines and immune responses to infection, and multiple polymorphisms of the IFR5 gene have been shown… read more here.
Keywords: interferon regulatory; regulatory factor; community acquired; factor ... See more keywords
Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses
Sign Up to like & getrecommendations! Published in 2019 at "Nature microbiology"
DOI: 10.1038/s41564-019-0425-6
Abstract: Current models of cell-intrinsic immunity to RNA viruses centre on virus-triggered inducible antiviral responses initiated by RIG-I-like receptors or Toll-like receptors that sense pathogen-associated molecular patterns, and signal downstream through interferon regulatory factors (IRFs), transcription… read more here.
Keywords: basal expression; rna viruses; interferon regulatory; rna ... See more keywords
HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2106017118
Abstract: Significance Clinical studies have shown that defects in type I interferon (IFN) production or antibodies to IFN appear to correlate with severe COVID-19 infection. Here, we demonstrate that proinflammatory cytokines but not type I IFN… read more here.
Keywords: production; interferon regulatory; interferon; type ifn ... See more keywords
Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehab920
Abstract: AIMS Inflammation is a key factor in atherosclerosis. The transcription factor interferon regulatory factor-5 (IRF5) drives macrophages towards a pro-inflammatory state. We investigated the role of IRF5 in human atherosclerosis and plaque stability. METHODS AND… read more here.
Keywords: plaque; factor; interferon regulatory; rupture ... See more keywords
Interferon regulatory factor-2 is required for the establishment of the gut intraepithelial T cell compartment.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac058
Abstract: CD8αα + intestinal intraepithelial lymphocytes (iIELs) are known for their unique role in keeping the integrity of the intestinal epithelial barrier, but factors affecting the development of these cells have not been thoroughly understood. Here… read more here.
Keywords: tcr; cd8 tcr; factor; interferon regulatory ... See more keywords
Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2.
Sign Up to like & getrecommendations! Published in 2019 at "International immunology"
DOI: 10.1093/intimm/dxz019
Abstract: Innate lymphoid cells (ILCs), composed of heterogeneous populations of lymphoid cells, contribute critically to immune surveillance at mucosal surfaces. ILC subsets develop from common lymphoid progenitors through stepwise lineage specification. However, the composition and temporal… read more here.
Keywords: interferon regulatory; regulatory factor; generation; innate lymphoid ... See more keywords