Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2018.09.005
Abstract: Several evidences emphasize B-cell pathogenic roles in multiple sclerosis (MS). We performed transcriptome analyses on peripheral B cells from therapy-free patients and age/sex-matched controls. Down-regulation of two transcripts (interferon response factor 1-IRF1, and C-X-C motif… read more here.
Keywords: interferon response; multiple sclerosis; response factor; peripheral cells ... See more keywords
Identification of a small molecule that primes the type I interferon response to cytosolic DNA
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02776-z
Abstract: The type I interferon response plays a pivotal role in host defense against infectious agents and tumors, and promising therapeutic approaches rely on small molecules designed to boost this system. To identify such compounds, we… read more here.
Keywords: type interferon; response; interferon response; interferon ... See more keywords
ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.140332
Abstract: ETV6 is an ETS family transcription factor that plays a key role in hematopoiesis and megakaryocyte development. Our group and others have identified germline mutations in ETV6 resulting in autosomal dominant thrombocytopenia and predisposition to… read more here.
Keywords: etv6 germline; interferon response; hdac3 ncor2; response genes ... See more keywords
Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0183526
Abstract: Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European descent and caused by mutations in the CFTR gene. However, the disease severity is immensely variable even among patients with similar… read more here.
Keywords: ribosomal stalk; cystic fibrosis; type interferon; interferon response ... See more keywords
Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007559
Abstract: Type I interferon response plays a prominent role against viral infection, which is frequently disrupted by viruses. Here, we report Bcl-2 associated transcription factor 1 (Bclaf1) is degraded during the alphaherpesvirus Pseudorabies virus (PRV) and… read more here.
Keywords: bclaf1; type interferon; response; degraded alphaherpesvirus ... See more keywords
Role of Hypoxia in the Interferon Response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.821816
Abstract: In solid tumors, as the tumor grows and the disease progresses, hypoxic regions are often generated, but in contrast to most normal cells which cannot survive under these conditions, tumour cells adapt to hypoxia by… read more here.
Keywords: hypoxia interferon; interferon response; role hypoxia; hypoxia ... See more keywords
Grouper cGAS is a negative regulator of STING-mediated interferon response
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1092824
Abstract: Cyclic GMP-AMP synthase (cGAS) is one of the classical pattern recognition receptors that recognizes mainly intracytoplasmic DNA. cGAS induces type I IFN responses to the cGAS-STING signaling pathway. To investigate the roles of cGAS-STING signaling… read more here.
Keywords: grouper cgas; interferon response; eccgas; negative regulator ... See more keywords
Dysregulated Interferon Response Underlying Severe COVID-19
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DOI: 10.3390/v12121433
Abstract: Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at… read more here.
Keywords: dysregulated interferon; interferon response; covid; response underlying ... See more keywords
Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.61630
Abstract: Germline mutations in the Folliculin (FLCN) tumor suppressor gene cause Birt–Hogg–Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing carriers to kidney tumors. FLCN is a conserved, essential gene linked to diverse cellular processes but… read more here.
Keywords: tubular epithelial; human renal; flcn; interferon response ... See more keywords