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   Articles with "interferon response" as a keyword



Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients

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recommendations! Published in 2018 at "Journal of Neuroimmunology"

DOI: 10.1016/j.jneuroim.2018.09.005

Abstract: Several evidences emphasize B-cell pathogenic roles in multiple sclerosis (MS). We performed transcriptome analyses on peripheral B cells from therapy-free patients and age/sex-matched controls. Down-regulation of two transcripts (interferon response factor 1-IRF1, and C-X-C motif… read more here.

Keywords: interferon response; multiple sclerosis; response factor; peripheral cells ... See more keywords

Nanodiamonds Interact with Primary Human Macrophages and Dendritic Cells Evoking a Vigorous Interferon Response

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recommendations! Published in 2025 at "ACS Nano"

DOI: 10.1021/acsnano.4c18108

Abstract: Nanodiamonds (NDs) display several attractive features rendering them useful for medical applications such as drug delivery. However, the interactions between NDs and the immune system remain poorly understood. Here, we investigated amino-, carboxyl-, and poly(ethylene… read more here.

Keywords: primary human; cell; interferon response; dendritic cells ... See more keywords

PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-49342-6

Abstract: The differentiation of the stroma is a hallmark event during postnatal uterine development. However, the spatiotemporal changes that occur during this process and the underlying regulatory mechanisms remain elusive. Here, we comprehensively delineated the dynamic… read more here.

Keywords: stromal development; development; interferon response; cell ... See more keywords

Identification of a small molecule that primes the type I interferon response to cytosolic DNA

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-02776-z

Abstract: The type I interferon response plays a pivotal role in host defense against infectious agents and tumors, and promising therapeutic approaches rely on small molecules designed to boost this system. To identify such compounds, we… read more here.

Keywords: type interferon; response; interferon response; interferon ... See more keywords

Abstract 4369559: Systemic Lupus Erythematosus Exacerbates Cardiac and Renal Injury and Inflammation and Attenuates the Cardiac Type 1 Interferon Response in Female Mice

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recommendations! Published in 2025 at "Circulation"

DOI: 10.1161/circ.152.suppl_3.4369559

Abstract: Background: Autoimmune diseases affect ~10% of the population, the overwhelming majority of which are women. However, the impact of autoimmune disease, such as systemic lupus erythematosus (SLE), on outcomes following myocardial infarction (MI) are not… read more here.

Keywords: type interferon; mice; interferon response; inflammation ... See more keywords
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ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes

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recommendations! Published in 2020 at "JCI Insight"

DOI: 10.1172/jci.insight.140332

Abstract: ETV6 is an ETS family transcription factor that plays a key role in hematopoiesis and megakaryocyte development. Our group and others have identified germline mutations in ETV6 resulting in autosomal dominant thrombocytopenia and predisposition to… read more here.

Keywords: etv6 germline; interferon response; hdac3 ncor2; response genes ... See more keywords

Aberrant thymic architecture and enhanced interferon signaling in down syndrome

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-3010

Abstract: Disrupting the mechanisms of thymocyte development and central tolerance can severely affect the immune system and lead to autoimmune disease. It is well established that individuals with Down syndrome (DS) have an elevated risk of… read more here.

Keywords: interferon signaling; cell; medulla; scrna seq ... See more keywords

Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0183526

Abstract: Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European descent and caused by mutations in the CFTR gene. However, the disease severity is immensely variable even among patients with similar… read more here.

Keywords: ribosomal stalk; cystic fibrosis; type interferon; interferon response ... See more keywords

Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3

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recommendations! Published in 2019 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1007559

Abstract: Type I interferon response plays a prominent role against viral infection, which is frequently disrupted by viruses. Here, we report Bcl-2 associated transcription factor 1 (Bclaf1) is degraded during the alphaherpesvirus Pseudorabies virus (PRV) and… read more here.

Keywords: bclaf1; type interferon; response; degraded alphaherpesvirus ... See more keywords

Role of Hypoxia in the Interferon Response

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.821816

Abstract: In solid tumors, as the tumor grows and the disease progresses, hypoxic regions are often generated, but in contrast to most normal cells which cannot survive under these conditions, tumour cells adapt to hypoxia by… read more here.

Keywords: hypoxia interferon; interferon response; role hypoxia; hypoxia ... See more keywords

Grouper cGAS is a negative regulator of STING-mediated interferon response

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recommendations! Published in 2023 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2023.1092824

Abstract: Cyclic GMP-AMP synthase (cGAS) is one of the classical pattern recognition receptors that recognizes mainly intracytoplasmic DNA. cGAS induces type I IFN responses to the cGAS-STING signaling pathway. To investigate the roles of cGAS-STING signaling… read more here.

Keywords: grouper cgas; interferon response; eccgas; negative regulator ... See more keywords