Regulation of interferon signaling in response to gut microbes by autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Gut Microbes"
DOI: 10.1080/19490976.2019.1614395
Abstract: ABSTRACT The cellular degradative pathway of autophagy prevents unrestrained inflammatory signaling by removing intracellular microbes, damaged organelles, and other factors that trigger immune reactions. Consistent with this function, a common variant of the autophagy gene… read more here.
Keywords: gut; regulation interferon; gut microbes; response gut ... See more keywords
Direct type I interferon signaling in hepatocytes controls malaria
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2022.01.26.477934
Abstract: Malaria is a devastating disease impacting over half of the world’s population. Plasmodium parasites that cause malaria undergo obligatory development and replication in hepatocytes before infecting red blood cells and initiating clinical disease. While type… read more here.
Keywords: type; plasmodium; interferon signaling; direct type ... See more keywords
Abstract 1800: Progesterone receptor attenuates STAT1-mediated interferon signaling in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1800
Abstract: Why some tumors remain indolent and others progress to clinical relevance remains a major unanswered question in cancer biology. Interferon signaling in nascent tumors, mediated by STAT1, is a critical step through which the surveilling… read more here.
Keywords: progesterone receptor; interferon; breast cancer; cancer ... See more keywords
Abstract 5964: Context-dependent induction of interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5964
Abstract: Chronic activation of inflammatory pathways and suppressed interferon signaling are hallmarks of myeloid cells in immunosuppressive tumors that drive poor responsiveness to conventional and immune therapies. Previous studies have identified agonistic activation of the CD11b… read more here.
Keywords: interferon signaling; tumor immunity; cancer; anti tumor ... See more keywords
Expression of the MHC class II in triple-negative breast cancer is associated with tumor-infiltrating lymphocytes and interferon signaling
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DOI: 10.1371/journal.pone.0182786
Abstract: Tumor-infiltrating lymphocytes (TILs) have been known for their strong prognostic and predictive significance in triple-negative breast cancer (TNBC). Several mechanisms for TIL influx in TNBC have been elucidated. Major histocompatibility complex class II (MHC-II) is… read more here.
Keywords: class; expression; mhc; cancer ... See more keywords
African swine fever virus pA104R protein acts as a suppressor of type I interferon signaling
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1169699
Abstract: This study evaluates the role of the late viral protein, pA104R, in African swine fever virus immunosuppression. ASFV-encoded pA104R is a putative histone-like protein that is highly conserved throughout different virulent and non-virulent isolates. Previous… read more here.
Keywords: pa104r; interferon signaling; african swine; type interferon ... See more keywords
Extracellular domain of semaphorin 5A serves a tumor‑suppressing role by activating interferon signaling pathways in lung adenocarcinoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of oncology"
DOI: 10.3892/ijo.2022.5311
Abstract: Semaphorin 5A (SEMA5A), which was originally identified as an axon guidance molecule in the nervous system, has been subsequently identified as a prognostic biomarker for lung cancer in nonsmoking women. SEMA5A acts as a tumor… read more here.
Keywords: interferon signaling; extracellular domain; lung adenocarcinoma;