Interferon stimulated genes and innate immune activation following infection with hepatitis B and C viruses
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24659
Abstract: Although not directly cytopathic, hepatitis B and C viruses (HBV and HCV) are responsible for millions of deaths per year, and the aging patient population presents a severe public health challenge. Most cases of acute… read more here.
Keywords: hepatitis viruses; hepatitis; genes innate; activation ... See more keywords
Identification of new type I interferon-stimulated genes and investigation of their involvement in IFN-β activation
Sign Up to like & getrecommendations! Published in 2018 at "Protein & Cell"
DOI: 10.1007/s13238-018-0511-1
Abstract: Virus infection induces the production of type I interferons (IFNs). IFNs bind to their heterodimeric receptors to initiate downstream cascade of signaling, leading to the up-regulation of interferon-stimulated genes (ISGs). ISGs play very important roles… read more here.
Keywords: ifn; interferon; activation; type ... See more keywords
Regulation and action of interferon-stimulated gene 15 in breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Human Cell"
DOI: 10.1007/s13577-020-00414-x
Abstract: Interferon-stimulated gene 15 (ISG15) is a critical ubiquitin-like protein that can be conjugated to proteins via the ISGylation system to modify them posttranslationally. Furthermore, ISG15 can be detected as non-conjugated or free, intracellularly and/or extracellularly.… read more here.
Keywords: cancer; interferon stimulated; stimulated gene; breast cancer ... See more keywords
Interplay between interferon-stimulated gene 15/ISGylation and interferon gamma signaling in breast cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.11.021
Abstract: Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like protein that conjugates to its target proteins to modify them through ISGylation, but the relevance of ISG15 expression and its effects have been not completely defined. Herein, we… read more here.
Keywords: interferon stimulated; isgylation; breast cancer;
DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.085
Abstract: The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs) to avoid inappropriate expression. Pathological ISG activation resulting from aberrant nucleic acid metabolism has been implicated in autoimmune disease; however, the mechanisms governing ISG… read more here.
Keywords: ddx6; activation; stimulated genes; interferon stimulated ... See more keywords
ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.132
Abstract: SUMMARY Post-translational modification of ribosomal subunit proteins (RPs) is emerging as an important means of regulating gene expression. Recently, regulatory ubiquitination of small RPs RPS10 and RPS20 by the ubiquitin ligase ZNF598 was found to… read more here.
Keywords: znf598; poxvirus; gene expression; expression ... See more keywords
Regulation of interferon stimulated gene expression levels at homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.154870
Abstract: Interferon stimulated genes (ISGs), a collection of genes important in the early innate immune response, are upregulated in response to stimulation by extracellular type I interferons. The regulation of ISGs has been extensively studied in… read more here.
Keywords: homeostasis; expression; expression levels; interferon stimulated ... See more keywords
Insights into the Porcine Reproductive and Respiratory Syndrome Virus Viral Ovarian Tumor Domain Protease Specificity for Ubiquitin and Interferon Stimulated Gene Product 15.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00068
Abstract: Porcine reproductive and respiratory syndrome (PRRS) is a widespread economically devastating disease caused by PRRS virus (PRRSV). First recognized in the late 1980s, PRRSV is known to undergo somatic mutations and high frequency viral recombination,… read more here.
Keywords: protease; porcine reproductive; reproductive respiratory; virus ... See more keywords
Immunoproteasome activation enables human TRIM5α restriction of HIV-1
Sign Up to like & getrecommendations! Published in 2019 at "Nature microbiology"
DOI: 10.1038/s41564-019-0402-0
Abstract: Type 1 interferon suppresses viral replication by upregulating the expression of interferon-stimulated genes with diverse antiviral properties1. The replication of human immunodeficiency virus type 1 (HIV-1) is naturally inhibited by interferon, with the steps between… read more here.
Keywords: restriction; hiv; infection; interferon ... See more keywords
BmCH25H, a vertebrate interferon‐stimulated gene(ISG) homolog, inhibits BmNPV infection dependent on its hydroxylase activity in Bombyx mori
Sign Up to like & getrecommendations! Published in 2022 at "Insect Science"
DOI: 10.1111/1744-7917.13102
Abstract: Cholesterol‐25‐hydroxylase (CH25H) has been identified as an interferon‐stimulated gene (ISG) in mammals that exerts its antiviral effects by catalyzing the conversion of cholesterol to 25‐hydroxycholesterol (25HC). However, invertebrates lack an antiviral system homologous to vertebrate… read more here.
Keywords: gene isg; infection; bmch25h; stimulated gene ... See more keywords
Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00744-17
Abstract: ABSTRACT Viruses manipulate the complex interferon and interferon-stimulated gene (ISG) system in different ways. We have previously shown that HIV inhibits type I and III interferons in its key target cells but directly stimulates a… read more here.
Keywords: hiv; interferon; stimulated gene; induction ... See more keywords