Intergenic variants may predispose to major depression disorder through regulation of long non-coding RNA expression.
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DOI: 10.1016/j.gene.2016.11.041
Abstract: Genome-wide association (GWA) studies have identified numerous genetic variants for major depressive disorder (MDD) although most of the genetic variants are intergenic. It has been found that approximately 54% of long non-coding RNAs (lncRNAs) are… read more here.
Keywords: disorder; long non; variants may; non coding ... See more keywords
Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121333119
Abstract: Significance An increased risk of stroke is associated with the presence of high-risk genetic variants in the intergenic region between FOXF2 and FOXQ1. We show that some variants are present in a short genomic region… read more here.
Keywords: transcriptional enhancer; stroke associated; intergenic variants; risk ... See more keywords