Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.04.020
Abstract: Abstract The objective of this study was to characterize the impact of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors, on interictal spikes and high‐frequency oscillations (ripples:… read more here.
Keywords: interictal spikes; mesial temporal; fast ripples; model mesial ... See more keywords
Temporal lobe interictal spikes disrupt encoding and retrieval of verbal memory: A subregion analysis
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DOI: 10.1111/epi.17334
Abstract: The medial temporal lobe (MTL) encodes and recalls memories and can be a predominant site for interictal spikes (IS) in patients with focal epilepsy. It is unclear whether memory deficits are due to IS in… read more here.
Keywords: spikes disrupt; temporal lobe; interictal spikes; memory ... See more keywords
Excitatory-inhibitory mismatch shapes node recruitment in an epileptic network.
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DOI: 10.1111/epi.17638
Abstract: OBJECTIVE Focal epilepsy is thought to be a network disease, in which epileptiform activity can spread non-contiguously through the brain via highly interconnected nodes, or hubs, within existing networks. Animal models confirming this hypothesis are… read more here.
Keywords: network; interictal spikes; node recruitment; excitatory inhibitory ... See more keywords