PP52 Interim Decision-Making To Address Uncertainty At Early Assessment
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DOI: 10.1017/s0266462319002071
Abstract: Introduction Medicines regulation has become increasingly adaptive to support earlier patient access but the immature clinical data is often challenging for health technology assessment decision-makers due to high levels of uncertainty on long term risks… read more here.
Keywords: interim decision; medicine; uncertainty; decision making ... See more keywords
Interim decision-making strategies in adaptive designs for population selection using time-to-event endpoints
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DOI: 10.1080/10543406.2016.1148714
Abstract: ABSTRACT Adaptive designs in oncology clinical trials with interim analyses for population selection could be used in the development of targeted therapies if a predefined biomarker hypothesis exists. In this article, we consider an interim… read more here.
Keywords: decision; population selection; adaptive designs; decision making ... See more keywords