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Published in 2017 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22083
Abstract: We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent‐liberated nuclei that are simultaneously stained with propidium iodide and labeled with fluorescent antibodies against p53, γH2AX, and phospho‐histone H3.…
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Keywords:
analysis;
vitro genotoxicity;
genotoxicity assay;
interlaboratory evaluation ... See more keywords
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Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062855
Abstract: In the quest to market increasingly safer and more potent biotherapeutic proteins, the concept of the multi-attribute method (MAM) has emerged from biopharmaceutical companies to boost the quality-by-design process development. MAM strategies rely on state-of-the-art…
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Keywords:
interlaboratory evaluation;
attribute;
mam;
user friendly ... See more keywords