Hyperforin protects against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.08.023
Abstract: Hyperforin, a pharmacologically active component of the medicinal plant Hypericum perforatum (St. John's wort), has been shown to be neuroprotective against acute ischemic stroke. However, the underlying mechanisms are still unclear and need to be… read more here.
Keywords: acute cerebral; interleukin 17a; activation; injury ... See more keywords
Co-expression of Interleukin-17A molecular adjuvant and prophylactic Helicobacter pylori genetic vaccine could cause sterile immunity in Treg suppressed mice.
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DOI: 10.1016/j.cyto.2019.154866
Abstract: The increasing clinical significance of Helicobacter pylori (H. pylori) in human stomach cancer has led to global efforts to eradicate this pathogen. Recent studies have confirmed the importance of some cytokines such as Interleukin-18 (IL-18),… read more here.
Keywords: immunity; interleukin 17a; helicobacter; helicobacter pylori ... See more keywords
The effects of interleukin 17A on left stellate ganglion remodeling are mediated by neuroimmune communication in normal structural hearts.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.01.010
Abstract: BACKGROUND It is reported interleukin (IL)-17A, a classical proinflammatory cytokine, is implicated in neuroimmune-associated remodeling in neural plasticity and pathological conditions. However, the effect of IL-17A on left stellate ganglion (LSG) remodeling remains unclear. OBJECTIVE… read more here.
Keywords: lsg; left stellate; group; interleukin 17a ... See more keywords
A novel fusion protein attenuates collagen–induced arthritis by targeting interleukin 17A and tumor necrosis factor &agr;
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.05.058
Abstract: Graphical abstract Figure. No caption available. ABSTRACT This study was undertaken to generate a novel dual targeting fusion protein (DTF), targeting tumor necrosis factor &agr; (TNF‐&agr;) and interleukin 17A (IL‐17A), and determine its anti‐arthritis properties… read more here.
Keywords: interleukin 17a; collagen induced; tumor necrosis; factor agr ... See more keywords
Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.01.002
Abstract: Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this study, we find… read more here.
Keywords: il17a mice; myeloid cells; interleukin 17a; 17a serves ... See more keywords
Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00422
Abstract: Interleukin 17A (IL-17A) is an interleukin cytokine whose dysregulation is implicated in autoimmune disorders such as psoriasis, and monoclonal antibodies against the IL-17A pathway are now well-established and very effective treatments. This article outlines the… read more here.
Keywords: interaction modulator; protein protein; protein interaction; rule compliant ... See more keywords
Association of microRNA-155, interleukin 17A, and proteinuria in preeclampsia
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DOI: 10.1097/md.0000000000006509
Abstract: Background: This study aimed to explore the correlation between microRNA-155 (miR-155), interleukin 17A (IL-17), and late preeclampsia (PE) using biochemical parameters in maternal serum and urine. Methods: Sixty patients with PE were recruited to this… read more here.
Keywords: mir 155; microrna 155; group; interleukin 17a ... See more keywords
Association between interleukin-17A/F single nucleotide polymorphisms and susceptibility to osteoarthritis in a Chinese population
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DOI: 10.1097/md.0000000000014944
Abstract: Abstract Interleukin-17A/F (IL-17A/F) might play a role in the pathophysiology of osteoarthritis (OA), but several studies exploring the association between IL-17A/F single nucleotide polymorphisms and OA in different populations present inconsistent results. Thus, this case–control… read more here.
Keywords: 17a single; interleukin 17a; single nucleotide; population ... See more keywords
Effectiveness of interleukin-17A inhibitors in patients with ankylosing spondylitis: A protocol for systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000032224
Abstract: Background: Ankylosing spondylitis is a chronic immune-mediated inflammatory arthritis. Interleukin-17A (IL-17A) inhibitors is recognized as a novel therapeutic target for ankylosing spondylitis. However, there is still a lack of high-quality research evidence regarding the issues.… read more here.
Keywords: 17a inhibitors; review; analysis; interleukin 17a ... See more keywords
Persistence of interleukin (IL)‐17A+ T lymphocytes and IL‐17A expression in treatment‐resistant psoriatic plaques despite ustekinumab therapy
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DOI: 10.1111/bjd.15029
Abstract: With the widespread use of monoclonal antibodies directed against cytokines in the treatment of psoriasis, we are presented with opportunities to investigate paradigms in cutaneous immunology, notably with respect to the ongoing skin inflammation that… read more here.
Keywords: persistence interleukin; treatment; interleukin 17a; lymphocytes 17a ... See more keywords
Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8
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DOI: 10.1128/mbio.00402-22
Abstract: Patients infected with SARS-CoV-2 variants lacking open reading frame 8 (ORF8) have been associated with milder infection and disease outcome, but the molecular mechanism behind how this viral accessory protein mediates disease pathogenesis is not… read more here.
Keywords: cov orf8; viral mimicry; orf8 viral; interleukin 17a ... See more keywords