Rilonacept (Interleukin-1 Inhibition) for the Treatment of Pericarditis
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DOI: 10.1007/s11886-021-01621-0
Abstract: Purpose of Review We reviewed the contemporary literature and clinical trials to discuss the applications of the interleukin-1 (IL-1) inhibitor rilonacept to treat pericarditis, with regards to pathophysiology, pharmacology, efficacy, and safety. Recent Findings Rilonacept… read more here.
Keywords: treatment pericarditis; interleukin inhibition; pericarditis; recurrent pericarditis ... See more keywords
Does interleukinâ4 inhibition play a role in dupilumabâassociated conjunctivitis?
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DOI: 10.1111/bjd.18450
Abstract: In the article "Goblet cell scarcity and conjunctival inflammation during treatment with dupilumab in patients with atopic dermatitis," Bakker et al. suggest that dupilumab-associated conjunctivitis occurs because the "IL -13 blocking effect of dupilumab might… read more here.
Keywords: associated conjunctivitis; conjunctivitis; interleukin inhibition; dupilumab ... See more keywords
Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation
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DOI: 10.1371/journal.pone.0208321
Abstract: Increased proinflammatory interleukin-6 (IL-6) levels are associated with acquired long QT-syndrome (LQTS) in patients with systemic inflammation, leading to higher risks for life-threatening polymorphic ventricular tachycardia such as Torsades de Pointes. However, the functional and… read more here.
Keywords: herg; acquired long; systemic inflammation; interleukin inhibition ... See more keywords
Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma Relief
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DOI: 10.3390/ijms231911166
Abstract: Interleukin 5 (IL-5) is a major cytokine responsible for eosinophil proliferation, migration and degranulation. Eosinophils play a considerable role in the manifestation of type 2 asthma, and therefore this makes IL-5 a unique and clinically… read more here.
Keywords: advances interleukin; asthma; breather advances; inhibition asthma ... See more keywords