Astrocyte immunosenescence and deficits in interleukin 10 signaling in the aged brain disrupt the regulation of microglia following innate immune activation
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24147
Abstract: Microglia, the innate immune cells of the brain, develops a pro‐inflammatory, “primed” profile with age. Using single‐cell RNA‐sequencing, we confirmed hippocampal microglia of aged mice (18 m.o.) had an amplified (4 h) and prolonged (24 h) neuroinflammatory… read more here.
Keywords: response; brain; microglia; interleukin signaling ... See more keywords
Localization of interleukin-6 signaling complex in epithelialized apical lesions of endodontic origin.
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DOI: 10.1007/s00784-020-03738-y
Abstract: OBJECTIVES We aimed to determine the immunolocalization patterns of the interleukin (IL)-6 signaling complex in epithelialized and non-epithelialized apical lesions of endodontic origin (ALEOs). MATERIALS AND METHODS Epithelialized (n = 8) and non-epithelialized (n = 7) ALEOs were obtained… read more here.
Keywords: signaling complex; apical lesions; epithelialized apical; interleukin signaling ... See more keywords
The placental interleukin-6 signaling controls fetal brain development and behavior
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2016.11.007
Abstract: Epidemiological studies show that maternal immune activation (MIA) during pregnancy is a risk factor for autism. However, mechanisms for how MIA affects brain development and behaviors in offspring remain poorly described. To determine whether placental… read more here.
Keywords: placental interleukin; fetal brain; mia; interleukin signaling ... See more keywords
SorLA in Interleukin-6 Signaling and Turnover
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DOI: 10.1128/mcb.00641-16
Abstract: ABSTRACT Interleukin-6 (IL-6) is a multifunctional cytokine with important functions in various physiologic processes. Mice lacking IL-6 exhibit multiple phenotypic abnormalities, such as an inadequate immune and acute-phase response, and elevated levels of circulating IL-6… read more here.
Keywords: signaling turnover; sorla; biology; interleukin signaling ... See more keywords
Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice
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DOI: 10.1186/s12974-017-0990-7
Abstract: BackgroundThe physiological and behavioral symptoms of sickness, including fever, anorexia, behavioral depression, and weight loss can be both beneficial and detrimental. These sickness responses are triggered by pro-inflammatory cytokines acting on cells within the brain.… read more here.
Keywords: cells within; responses mice; sickness responses; fenestrated capillaries ... See more keywords
A Chinese Patent Medicine JiaYanKangTai Alleviates Inflammatory Lesions of Experimental Autoimmune Thyroiditis by Regulating Interleukin-17 Signaling
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DOI: 10.3389/fendo.2021.794568
Abstract: Objective This study was aimed to investigate the effects of JiaYanKangTai (JYKT) on regulating interleukin-17 (IL-17) signaling in rats with autoimmune thyroiditis. Methods Lewis rats were administrated with JYKT for eight weeks after a seven-week… read more here.
Keywords: jykt; interleukin signaling; autoimmune thyroiditis; regulating interleukin ... See more keywords
Somatic Mutations Alter Interleukin Signaling Pathways in Grade II Invasive Breast Cancer Patients: An Egyptian Experience
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DOI: 10.3390/cimb44120401
Abstract: This study aimed to investigate the impact of somatic mutations on various interleukin signaling pathways associated with grade II invasive breast cancer (BC) in Egyptian patients to broaden our understanding of their role in promoting… read more here.
Keywords: invasive breast; interleukin signaling; somatic mutations; signaling pathways ... See more keywords