Therapeutic Targeting of Interleukin-11 Signalling Reduces Pressure Overload–Induced Cardiac Fibrosis in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-020-10054-z
Abstract: There are currently no specific treatments for cardiac fibrosis. We tested the efficacy of a neutralising anti-IL11 antibody (X203) to reduce cardiac fibrosis in two preclinical models: transverse aortic constriction (TAC) and chronic angiotensin II… read more here.
Keywords: targeting interleukin; fibrosis; cardiac fibrosis; therapeutic targeting ... See more keywords
Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression
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DOI: 10.1093/rheumatology/kew336
Abstract: Objectives. The overexpression of IL-12 family cytokines is implicated in the pathogenesis of SSc, but their exact role is still unclear. The aim of this study was to investigate the regulation of extracellular matrix expression… read more here.
Keywords: collagen; ssc; ssc fibroblasts; expression ... See more keywords
Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD
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DOI: 10.1183/13993003.00563-2019
Abstract: Asthma and chronic obstructive pulmonary disease (COPD) cause significant morbidity and mortality worldwide. In the context of disease pathogenesis, both asthma and COPD involve chronic inflammation of the lung and are characterised by the abnormal… read more here.
Keywords: asthma; interleukin signalling; pathogenesis asthma; asthma copd ... See more keywords