Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0224644
Abstract: Polybrominated diphenyl ethers (PBDEs) were formally used as flame-retardants and are chemically stable, lipophlic persistent organic pollutants which are known to bioaccumulate in humans. Although its toxicities are well characterized, little is known about the… read more here.
Keywords: involved intermediary; pcg pairs; metabolism; intermediary metabolism ... See more keywords
Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-20-0176
Abstract: Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. Early studies identified ME1 as a mediator of intermediary metabolism primarily through its… read more here.
Keywords: enzyme me1; malic enzyme; intermediary metabolism; me1 ... See more keywords
Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2018.204701
Abstract: BH3 mimetics are novel targeted drugs with remarkable specificity, potency and enormous potential to improve cancer therapy. However, acquired resistance is an emerging problem. We report the rapid development of resistance in chronic lymphocytic leukemia… read more here.
Keywords: efficacy bh3; intermediary metabolism; mimetic therapy; resistance ... See more keywords
Myocardial disturbances of intermediary metabolism in Barth syndrome
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DOI: 10.3389/fcvm.2022.981972
Abstract: Barth Syndrome (BTHS) is a rare X-linked mitochondrial disorder due to mutations in the gene TAFAZZIN, which leads to immature cardiolipin (CL) remodeling and is characterized by the development of cardiomyopathy. The immature CL remodeling… read more here.
Keywords: metabolism; metabolism barth; barth syndrome; disturbances intermediary ... See more keywords
The Fate and Intermediary Metabolism of Soyasapogenol in the Rat
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DOI: 10.3390/molecules28010284
Abstract: Research suggests that soyasaponins are poorly absorbed in the GI tract and that soyasaponin aglycones or soyasapogenols are absorbed faster and in greater amounts than the corresponding soyasaponins. Therefore, it is important to understand the… read more here.
Keywords: soyasapogenol; rat; soyasapogenol rat; metabolism soyasapogenol ... See more keywords