UV Excitation of Uracil Results in the Formation of a Ground-State Intermediate in Less Than One Picosecond and Its Decay is Quenched by Nucleophilic Water Addition.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c16116
Abstract: Investigating the excited-state dynamics of RNA is essential for understanding potential damage to biological systems, developing new biotechnologies, and gaining fundamental insights into molecular behavior and the chemical evolution of life on Earth. In this… read more here.
Keywords: water addition; state; ground state; intermediate ... See more keywords
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression
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DOI: 10.1038/s41467-019-10152-w
Abstract: The beta-site APP cleaving enzyme 1 (BACE1) is known primarily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads to the generation of Aβ peptides. Here, we provide evidence that altered… read more here.
Keywords: degradation; alzheimer disease; intermediate; clearance ... See more keywords
Unleashing the Power of Intermediate Domains for Mixed Domain Semi-Supervised Medical Image Segmentation
Sign Up to like & getrecommendations! Published in 2025 at "IEEE Transactions on Medical Imaging"
DOI: 10.1109/tmi.2025.3575162
Abstract: Both limited annotation and domain shift are prevalent challenges in medical image segmentation. Traditional semi-supervised segmentation and unsupervised domain adaptation methods address one of these issues separately. However, the coexistence of limited annotation and domain… read more here.
Keywords: segmentation; medical image; image segmentation; semi supervised ... See more keywords
Identification of Ketene-Reactive Intermediate of Erlotinib Possibly Responsible for Inactivation of P450 Enzymes
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DOI: 10.1124/dmd.117.079327
Abstract: Erlotinib (ELT), a tyrosine kinase inhibitor, is widely used for the treatment of nonsmall cell lung cancer in clinic. Unfortunately, severe drug-induced liver injury and other adverse effects occurred during the treatment. Meanwhile, ELT has… read more here.
Keywords: inactivation; erlotinib; p450; intermediate ... See more keywords
Early-onset phenotype in a patient with an intermediate allele and a large SCA1 expansion: a case report
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DOI: 10.1186/s12883-024-03846-2
Abstract: Spinocerebellar ataxia type 1, is a rare neurodegenerative disorder with autosomal dominant inheritance belonging to the polyglutamine diseases. The diagnosis of this disease requires genetic testing that may also include the search for CAT interruption… read more here.
Keywords: intermediate allele; large sca1; sca1 expansion; allele large ... See more keywords
Transcatheter Arterial Chemoembolization in Combination With High-Intensity Focused Ultrasound for Intermediate and Advanced Hepatocellular Carcinoma: A Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.797349
Abstract: Background The study was conducted to explore whether high-intensity focused ultrasound (HIFU) can improve the effect of transcatheter arterial chemoembolization (TACE) in intermediate and advanced hepatocellular carcinoma (HCC). Methods PubMed, Embase, Cochrane Library, Web of… read more here.
Keywords: meta analysis; intermediate; combination; intermediate advanced ... See more keywords