Inhibition of platelet aggregation by activation of platelet intermediate conductance Ca2+‐activated potassium channels
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15827
Abstract: Within the vasculature platelets and endothelial cells play crucial roles in hemostasis and thrombosis. Platelets, like endothelial cells, possess intermediate conductance Ca2+‐activated K+ (IKCa) channels and generate nitric oxide (NO). Although NO limits platelet aggregation,… read more here.
Keywords: conductance ca2; ca2 activated; intermediate conductance; platelet aggregation ... See more keywords
Structure, Gating and Basic Functions of the Ca2+-activated K Channel of Intermediate Conductance
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DOI: 10.2174/1570159x15666170830122402
Abstract: Background The KCa3.1 channel is the intermediate-conductance member of the Ca2+-activated K channel superfamily. It is widely expressed in excitable and non-excitable cells, where it plays a major role in a number of cell functions.… read more here.
Keywords: kca3 channel; channel intermediate; intermediate conductance; ca2 ... See more keywords
LY294002 Inhibits Intermediate Conductance Calcium-Activated Potassium (KCa3.1) Current in Human Glioblastoma Cells
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DOI: 10.3389/fphys.2021.790922
Abstract: Glioblastomas (GBs) are among the most common tumors with high malignancy and invasiveness of the central nervous system. Several alterations in protein kinase and ion channel activity are involved to maintain the malignancy. Among them,… read more here.
Keywords: calcium; intermediate conductance; kca3 current; conductance calcium ... See more keywords