Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities.
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DOI: 10.1158/0008-5472.can-22-1577
Abstract: Malignant gliomas such as glioblastoma are highly heterogeneous with distinct cells of origin and varied genetic alterations. It remains elusive whether the specific states of neural cell lineages are differentially susceptible to distinct genetic alterations… read more here.
Keywords: intermediate lineage; loss induced; pten p53; p53 loss ... See more keywords