TLR8 is activated by 5'-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway.
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DOI: 10.1016/j.celrep.2022.110691
Abstract: The innate immune recognition of the malaria-causing pathogen Plasmodium falciparum (P. falciparum) is not fully explored. Here, we identify the nucleoside 5'-methylthioinosine (MTI), a Plasmodium-specific intermediate of the purine salvage pathway, as a pathogen-derived Toll-like receptor… read more here.
Keywords: plasmodium; intermediate purine; purine salvage; salvage pathway ... See more keywords