Diastereoselective Synthesis of an Advanced Intermediate of Thapsigargin and Other 6,12-Guaianolides Using a RCEYM Strategy.
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DOI: 10.1021/acs.orglett.8b00456
Abstract: A new and flexible approach toward the synthesis of 6,12-guaianolide anticancer drugs such as trilobolides or thapsigargin has been developed that could be applied to the preparation of analogues with a modified ring system. The… read more here.
Keywords: advanced intermediate; intermediate thapsigargin; diastereoselective synthesis; synthesis advanced ... See more keywords