Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca2+ homeostasis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3538
Abstract: Obstructive sleep apnea syndrome (OSAS) is an important consequence of chronic intermittent hypoxia (CIH). Astragaloside IV (AS-IV) exerts multiple protective effects in diverse diseases. However, whether AS-IV can attenuate CIH-induced myocardial injury is unclear. In… read more here.
Keywords: induced myocardial; myocardial injury; cih; intermittent hypoxia ... See more keywords
Intermittent hypoxia promotes carcinogenesis in azoxymethane and dextran sodium sulfate‐induced colon cancer model
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DOI: 10.1002/mc.22957
Abstract: Intermittent hypoxia (IH), a characteristic of obstructive sleep apnea, is known to promote cancer progression and aggressiveness in mouse models. However, little is known regarding the effect of IH on cancer initiation. Here, the effect… read more here.
Keywords: dextran sodium; colon cancer; cancer; induced colon ... See more keywords
Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions
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DOI: 10.1007/s00213-020-05663-0
Abstract: Rationale The hypoglossal nucleus (HN) controls the movement of the genioglossus (GG) muscle whose dysfunction leads to airway occlusion and occurrence of obstructive sleep apnea (OSA). Histamine produced by the tuberomammillary nucleus (TMN) has a… read more here.
Keywords: hypoglossal nucleus; histamine; activity; intermittent hypoxia ... See more keywords
Impact of age on intermittent hypoxia in obstructive sleep apnea: a propensity-matched analysis
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DOI: 10.1007/s11325-017-1560-z
Abstract: PurposeTo determine independent relationship of aging with chronic intermittent hypoxia, we compared hypoxia-related polysomnographic variables of geriatric patients (aged ≥ 65 years) with an apnea–hypopnea index (AHI)-, gender-, body mass index (BMI)-, and neck circumference-matched cohort of… read more here.
Keywords: matched analysis; apnea; geriatric patients; hypoxia ... See more keywords
Toll-like receptor-4 deficiency alleviates chronic intermittent hypoxia-induced renal injury, inflammation, and fibrosis
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DOI: 10.1007/s11325-018-1704-9
Abstract: BackgroundObstructive sleep apnea (OSA)-associated chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH) triggered renal damage. This study aims to investigate the role of toll-like receptor-4 (TLR4) in underlying mechanism involved chronic intermittent… read more here.
Keywords: cih; deficiency; tlr4; injury ... See more keywords
Intermittent hypoxia causes mandibular growth retardation and macroglossia in growing rats
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Orthodontics and Dentofacial Orthopedics"
DOI: 10.1016/j.ajodo.2016.02.033
Abstract: Introduction: In this study, we aimed to examine the role of intermittent hypoxia (IH) in dentofacial morphologic changes in growing rats. Methods: Seven‐week‐old male rats were exposed to IH at 20 cycles per hour (nadir… read more here.
Keywords: group; rats intermittent; growing rats; growth ... See more keywords
Tim-3 is a potential regulator that inhibits monocyte inflammation in response to intermittent hypoxia in children with obstructive sleep apnea syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108641
Abstract: The mechanism of the characteristic intermittent hypoxia (IH) of obstructive sleep apnea syndrome (OSAS) on monocyte remain unclear. Our study found that OSAS children had a significantly upregulated expression in circulating proinflammatory cytokines IL-6 and… read more here.
Keywords: obstructive sleep; sleep apnea; apnea syndrome; intermittent hypoxia ... See more keywords
Activation of the hypothalamic paraventricular nucleus by acute intermittent hypoxia: Implications for sympathetic long-term facilitation neuroplasticity
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.12.011
Abstract: &NA; Exposure to acute intermittent hypoxia (AIH) induces a progressive increase of sympathetic nerve activity (SNA) that reflects a form of neuroplasticity known as sympathetic long‐term facilitation (sLTF). Our recent findings indicate that activity of… read more here.
Keywords: aih induced; long term; pvn; neuroplasticity ... See more keywords
Alpha adrenergic receptor signaling in the hypothalamic paraventricular nucleus is diminished by the chronic intermittent hypoxia model of sleep apnea
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DOI: 10.1016/j.expneurol.2020.113517
Abstract: Chronic intermittent hypoxia (CIH) is a model for obstructive sleep apnea. The paraventricular nucleus (PVN) of the hypothalamus has been suggested to contribute to CIH-induced exaggerated cardiorespiratory reflexes, sympathoexcitation and hypertension. This may occur, in… read more here.
Keywords: cih; paraventricular nucleus; sleep apnea; intermittent hypoxia ... See more keywords
Factor Xa inhibition by rivaroxaban attenuates cardiac remodeling due to intermittent hypoxia.
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DOI: 10.1016/j.jphs.2018.07.002
Abstract: Patients with obstructive sleep apnea (OSA) have a high prevalence of atrial fibrillation (AF). Rivaroxaban, a coagulation factor Xa inhibitor, has recently been reported to show pleiotropic effects. This study investigated the influence of rivaroxaban… read more here.
Keywords: rivaroxaban attenuates; rivaroxaban; cardiac remodeling; factor ... See more keywords
Differential metabolic and inflammatory responses to intermittent hypoxia in substrains of lean and obese C57BL/6 mice.
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DOI: 10.1016/j.lfs.2019.116959
Abstract: AIMS This study was to investigate the degree of susceptibility to intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), between the two mice inbred lines C57BL/6N (6N) and C57BL/6J (6J). MATERIALS AND METHODS… read more here.
Keywords: inflammatory responses; metabolic inflammatory; c57bl mice; c57bl ... See more keywords