Intermittent treatment of BRAFV600E melanoma cells delays resistance by adaptive resensitization to drug rechallenge
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113535119
Abstract: Significance Preclinical studies of metastatic melanoma treated with targeted therapeutics have suggested that alternating periods of treatment and withdrawal might delay the onset of resistance. This has been attributed to drug addiction, where cells lose… read more here.
Keywords: drug rechallenge; intermittent treatment; resistance; resensitization ... See more keywords
Inhaled levodopa for intermittent treatment of OFF episodes in patients with Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2020.1724535
Abstract: ABSTRACT Introduction: Many patients with advanced Parkinson’s disease (PD) have inadequate control of motor symptoms despite optimized treatment. Predictable and unpredictable OFF periods severely interfere with the quality of life. A drug that easily and… read more here.
Keywords: treatment; intermittent treatment; inhaled levodopa; levodopa intermittent ... See more keywords