Catalytic asymmetric de novo construction of 4-pyrrolin-2-ones via intermolecular formal [3+2] cycloaddition of azoalkenes with azlactones.
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DOI: 10.1039/d3cc01194a
Abstract: The chiral phosphoric acid-catalyzed asymmetric intermolecular formal [3+2] cycloaddition of azoalkenes with azlactones has been established. This convergent protocol leads to a facile and enantioselective de novo construction of a wide range of fully substituted… read more here.
Keywords: azoalkenes azlactones; intermolecular formal; formal cycloaddition; novo construction ... See more keywords