Enantio- and Regioselective Ni-Catalyzed para-C-H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation.
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DOI: 10.1021/jacs.2c04043
Abstract: Direct asymmetric functionalization of the pyridyl C-H bond represents a longstanding challenge in organic chemistry. We herein describe the first enantioselective para-C-H activation of pyridines through the use of a Ni-Al bimetallic catalyst system and… read more here.
Keywords: intermolecular hydroarylation; enantio regioselective; regioselective catalyzed; catalyzed para ... See more keywords