Iron-Catalyzed Regiospecific Intermolecular Radical Cyclization of Anilines: Strategy for Assembly of 2,2-Disubstituted Indolines.
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DOI: 10.1021/acs.orglett.8b00176
Abstract: The first regiospecific catalytic intermolecular assembly of 2,2-disubstituted indolines has been developed. This protocol is based on a ligand and directing group free, iron-catalyzed radical [3 + 2] process, allowing efficient coupling of different N-sulfonylanilines… read more here.
Keywords: intermolecular radical; regiospecific intermolecular; iron catalyzed; assembly disubstituted ... See more keywords
A Counterion/Ligand-Tuned Chemo- and Enantioselective Copper-Catalyzed Intermolecular Radical 1,2-Carboamination of Alkenes.
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DOI: 10.1021/jacs.2c08035
Abstract: The copper-catalyzed enantioselective intermolecular radical 1,2-carboamination of alkenes with readily accessible alkyl halides is an appealing strategy for producing chiral amine scaffolds. The challenge arises from the easily occurring atom transfer radical addition between alkyl… read more here.
Keywords: copper; radical carboamination; ligand; copper catalyzed ... See more keywords
Catalyst-Free Synthesis of 1,4-Dihydroquinolines and Pyrrolo[1,2-a]quinolines via Intermolecular [4+2]/[3+2] Radical Cyclization of N-Methylanilines with Alkynoates
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DOI: 10.1055/s-0039-1691541
Abstract: Intermolecular [4+2]/[3+2] radical annulation of N-methylanilines with alkynoates under metal- and photoredox-catalyst-free conditions provides a practical and efficient method to synthesize bioactive 1,4-dihydroquinolines and pyrrolo[1,2-a]quinolines in one pot in moderate to high overall yields. read more here.
Keywords: intermolecular radical; free synthesis; dihydroquinolines pyrrolo; pyrrolo quinolines ... See more keywords