A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.
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DOI: 10.1016/j.ejmech.2021.113435
Abstract: The eukaryotic translation initiation factor 4E (eIF4E) is the master regulator of cap-dependent protein synthesis. Overexpression of eIF4E is implicated in diseases such as cancer, where dysregulation of oncogenic protein translation is frequently observed. eIF4E… read more here.
Keywords: inhibitor; eif4e; binding site; internal binding ... See more keywords