Existence of Internal N7-Methylguanosine Modification in mRNA Determined by Differential Enzyme Treatment Coupled with Mass Spectrometry Analysis.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00906
Abstract: The recent discovery of reversible chemical modifications on mRNA has opened a new era of post-transcriptional gene regulation in eukaryotes. Among the 15 types of modifications identified in mRNA of eukaryotes, N7-methylguanosine (m7G) is unique… read more here.
Keywords: spectrometry analysis; internal m7g; m7g; mass spectrometry ... See more keywords
IGF2BP3 promotes mRNA degradation through internal m7G modification
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DOI: 10.1038/s41467-024-51634-w
Abstract: Recent studies have suggested that mRNA internal m7G and its writer protein METTL1 are closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP family proteins IGF2BP1-3 can preferentially bind internal mRNA… read more here.
Keywords: cancer; m7g; degradation; m7g modification ... See more keywords