Copper-Catalyzed Intermolecular [4 + 2] Annulation Enabled by Internal Oxidant-Promoted C(sp3)-H Functionalization: Access to 3-Trifluoromethylated 3-Hydroxy-cyclohexan-1-ones.
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DOI: 10.1021/acs.orglett.9b01817
Abstract: A copper-catalyzed diastereoselective [4 + 2] cyclolization of α,β-unsaturated ketoxime acetates and trifluoromethyl ketones affords various 3-trifluoromethylated 3-hydroxy-cylcohexan-1-ones smoothly. This reaction features the selective functionalization of a less acidic C(sp3)-H bond by an internal oxdative… read more here.
Keywords: catalyzed intermolecular; trifluoromethylated hydroxy; sp3 functionalization; internal oxidant ... See more keywords