Biomimetic Nanovaccines Potentiating Dendritic Cell Internalization via CXCR4‐Mediated Macropinocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202064
Abstract: Although targeted delivery of nanoparticulate vaccines to dendritic cells (DCs) holds tremendous potential, it still faces insufficient internalization and endosome degradation via the receptor‐mediated endocytosis pathway. Inspired by the advantages of CXC‐chemokine receptor type 4… read more here.
Keywords: biomimetic nanovaccines; internalization; mediated macropinocytosis; macropinocytosis ... See more keywords
Monomer‐Dimer Equilibrium of Human Cystatin C During Internalization Into Cancer Cells
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400226
Abstract: Human cystatin C (hCC) is a physiologically important protein that serves as intra‐ and extracellular cysteine proteinase inhibitor in homeostasis. However, in pathological states it dimerizes and further oligomerizes accumulating into a toxic amyloid. HCC… read more here.
Keywords: internalization; oligomeric state; hcc; human cystatin ... See more keywords
Development and validation of the sociocultural attitudes towards appearance questionnaire‐4‐revised (SATAQ‐4R)
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Eating Disorders"
DOI: 10.1002/eat.22590
Abstract: OBJECTIVE The Sociocultural Attitudes Toward Appearance Questionnaire-4 (SATAQ-4) is a measure of internalization of appearance ideals (i.e., personal acceptance of societal ideals) and appearance pressures (i.e., pressures to achieve the societal ideal). The current study… read more here.
Keywords: sataq; college; internalization; appearance ... See more keywords
Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25673
Abstract: Laminin binding integrins α6 (CD49f) and α3 (CD49c) are persistently but differentially expressed in prostate cancer (PCa). Integrin internalization is an important determinant of their cell surface expression and function. Using flow cytometry, and first… read more here.
Keywords: internalization; prostate cancer; integrin internalization; cell ... See more keywords
Involvement of Integrin β3 O‐Glycosylation in Human Cytomegalovirus Internalization Into Fibroblasts
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70536
Abstract: Glycosylation of viral receptors is essential during the initial steps of viral infection. While integrin β3 has been recognized as a cellular receptor facilitating human cytomegalovirus (hCMV) entry into fibroblasts, the specific contribution of its… read more here.
Keywords: internalization fibroblasts; integrin; internalization; human cytomegalovirus ... See more keywords
A Method for High‐Throughput Screening of Monoclonal Antibody Internalization Using a DNA/Protein Molecular Staple
Sign Up to like & getrecommendations! Published in 2025 at "Small Methods"
DOI: 10.1002/smtd.202401399
Abstract: The use of monoclonal antibodies (mAbs) as therapeutics or for targeted delivery to specific cells is reliant on understanding mAb‐receptor interactions. Of particular importance is the relationship between mAb binding and internalization into cells. Internalization… read more here.
Keywords: receptor; internalization; method high; binding internalization ... See more keywords
Activation of Endosome-Associated Inert EGF Receptor Following Internalization.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7219-7_8
Abstract: Our current understanding of endosomal signaling is incomplete given our inability to generate endosomal signals in isolation from plasma membrane signals. We present a novel method to specifically activate epidermal growth factor (EGF) receptor (EGFR)… read more here.
Keywords: endosome associated; egf receptor; internalization; endosomal signaling ... See more keywords
Passive Internalization of Bioactive β-Casein Peptides into Phospholipid (POPC) Bilayers. Free Energy Landscapes from Unbiased Equilibrium MD Simulations at μs-Time Scale
Sign Up to like & getrecommendations! Published in 2020 at "Food Biophysics"
DOI: 10.1007/s11483-020-09651-x
Abstract: Absorption of bioactive peptides in the intestinal epithelium take place in the apical or the basolateral tight junctions of the cells. Depending on the peptide size and hydrophobicity, translocation mechanisms involve processes of passive diffusion,… read more here.
Keywords: peptide; simulations time; internalization; unbiased equilibrium ... See more keywords
Oxygen-Glucose Deprivation/Reoxygenation Induces Human Brain Microvascular Endothelial Cell Hyperpermeability Via VE-Cadherin Internalization: Roles of RhoA/ROCK2
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01326-8
Abstract: The destruction of the blood-brain barrier (BBB) contributes to a spectrum of neurological diseases such as stroke, and the hyperpermeability of endothelial cells is one of the characters of stroke, which is possibly exacerbated after… read more here.
Keywords: hbmec monolayers; hyperpermeability; internalization; glucose deprivation ... See more keywords
Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1580-8
Abstract: The current study was performed to establish the actions of nanomolar concentrations of cocaine, not blocking the dopamine transporter, on dopamine D2 receptor (D2R)-sigma 1 receptor (δ1R) heteroreceptor complexes and the D2R protomer recognition, signaling… read more here.
Keywords: d2r; internalization; heteroreceptor complexes; cocaine ... See more keywords
All-Trans Retinoic Acid-Induced Cell Surface Heat Shock Protein 90 Mediates Tau Protein Internalization and Degradation in Human Microglia
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Neurobiology"
DOI: 10.1007/s12035-024-04295-1
Abstract: This study investigates the role of all-trans retinoic acid (ATRA) in modulating the expression of heat shock protein 90 (Hsp90) and its influence on the uptake and degradation of tau proteins in immortalized human microglia… read more here.
Keywords: trans retinoic; degradation; tau protein; internalization ... See more keywords