Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202511472
Abstract: In addition to dementia, Alzheimer's patients suffer from sleep impairments and aberrations in sleep-dependent brain rhythms. Deficits in inhibitory GABAergic interneuron function disrupt one of those rhythms, slow oscillation in particular, and actively contribute to… read more here.
Keywords: progenitors restores; interneuron; function; gabaergic interneuron ... See more keywords
Selective plasticity of hippocampal GABAergic interneuron populations following kindling of different brain regions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24071
Abstract: The vulnerability and plasticity of hippocampal GABAergic interneurons is a topic of broad interest and debate in the field of epilepsy. In this experiment, we used the electrical kindling model of epilepsy to determine whether… read more here.
Keywords: plasticity hippocampal; hippocampal gabaergic; different brain; brain regions ... See more keywords
Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.111921
Abstract: Neonatal brain injury from hypoxia-ischemia (HI) causes major morbidity. Piglet HI is an established method for testing neuroprotective treatments in large, gyrencephalic brain. Though many neurobehavior tests exist for rodents, such tests and their associations… read more here.
Keywords: neuron loss; interneuron; spatial maze; loss ... See more keywords
Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108904
Abstract: GABAergic interneurons migrate long distances through stereotyped migration programs toward specific laminar positions. During their migration, GABAergic interneurons are morphologically alike but then differentiate into a rich array of interneuron subtypes critical for brain function.… read more here.
Keywords: inhibitory interneuron; migration; interneuron subtypes; differentiation ... See more keywords
Exploring the Interneuron Canopy Atop the ‘Impenetrable Jungle’
Sign Up to like & getrecommendations! Published in 2019 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2019.01.001
Abstract: The multifaceted functions of the brain are borne through seemingly infinite spatiotemporal interactions between its resident neural elements. Using a combinatorial approach, Schuman and colleagues (J. Neurosci. 2018;39:125-139) recently identify four layer 1 cortical interneuron… read more here.
Keywords: atop impenetrable; interneuron canopy; canopy; interneuron ... See more keywords
Heterogeneous plasticity of amygdala interneurons in associative learning and extinction
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-025-66122-y
Abstract: Neural circuits undergo experience-dependent plasticity to form long-lasting memories. Excitatory projection neurons are considered to be the primary neuronal substrate for memory acquisition and storage. However, inhibitory interneurons control the activity of projection neurons in… read more here.
Keywords: amygdala interneurons; interneuron; learning extinction; plasticity ... See more keywords
Regulation of PV interneuron plasticity by neuropeptide-encoding genes
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-025-08933-z
Abstract: Neuronal activity must be regulated in a narrow permissive band for the proper operation of neural networks. Changes in synaptic connectivity and network activity—for example, during learning—might disturb this balance, eliciting compensatory mechanisms to maintain… read more here.
Keywords: changes activity; neuropeptide encoding; interneuron; plasticity ... See more keywords
Cellular and molecular signatures of in vivo imaging measures of GABAergic neurotransmission in the human brain.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03268-1
Abstract: Diverse GABAergic interneuron networks orchestrate information processing in the brain. Understanding the principles underlying the organisation of this system in the human brain, and whether these principles are reflected by available non-invasive in vivo neuroimaging… read more here.
Keywords: gabaa receptor; gabaergic neurotransmission; human brain; interneuron ... See more keywords
Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebral cortex"
DOI: 10.1093/cercor/bhab152
Abstract: Cortical interneurons (GABAergic cells) arise during embryogenesis primarily from the medial and caudal ganglionic eminences (MGE and CGE, respectively) with a small population generated from the preoptic area (POA). Progenitors from the lateral ganglionic eminence… read more here.
Keywords: islet1 precursors; isl1; precursors contribute; population ... See more keywords
Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.abm2545
Abstract: Parvalbumin-positive (PV+) interneurons play a critical role in maintaining circuit rhythm in the brain, and their reduction is implicated in autism spectrum disorders. Animal studies demonstrate that maternal immune activation (MIA) leads to reduced PV+… read more here.
Keywords: parvalbumin positive; microglial gpr56; maternal immune; interneuron ... See more keywords
Connectomic comparison of mouse and human cortex
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abo0924
Abstract: The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex of a mouse, but the possible differences in synaptic circuits between these species are still poorly understood. We used three-dimensional… read more here.
Keywords: network; microscopy; mouse; mouse human ... See more keywords