Selective plasticity of hippocampal GABAergic interneuron populations following kindling of different brain regions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24071
Abstract: The vulnerability and plasticity of hippocampal GABAergic interneurons is a topic of broad interest and debate in the field of epilepsy. In this experiment, we used the electrical kindling model of epilepsy to determine whether… read more here.
Keywords: plasticity hippocampal; hippocampal gabaergic; different brain; brain regions ... See more keywords
Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.111921
Abstract: Neonatal brain injury from hypoxia-ischemia (HI) causes major morbidity. Piglet HI is an established method for testing neuroprotective treatments in large, gyrencephalic brain. Though many neurobehavior tests exist for rodents, such tests and their associations… read more here.
Keywords: neuron loss; interneuron; spatial maze; loss ... See more keywords
Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108904
Abstract: GABAergic interneurons migrate long distances through stereotyped migration programs toward specific laminar positions. During their migration, GABAergic interneurons are morphologically alike but then differentiate into a rich array of interneuron subtypes critical for brain function.… read more here.
Keywords: inhibitory interneuron; migration; interneuron subtypes; differentiation ... See more keywords
Exploring the Interneuron Canopy Atop the ‘Impenetrable Jungle’
Sign Up to like & getrecommendations! Published in 2019 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2019.01.001
Abstract: The multifaceted functions of the brain are borne through seemingly infinite spatiotemporal interactions between its resident neural elements. Using a combinatorial approach, Schuman and colleagues (J. Neurosci. 2018;39:125-139) recently identify four layer 1 cortical interneuron… read more here.
Keywords: atop impenetrable; interneuron canopy; canopy; interneuron ... See more keywords
Cellular and molecular signatures of in vivo imaging measures of GABAergic neurotransmission in the human brain.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03268-1
Abstract: Diverse GABAergic interneuron networks orchestrate information processing in the brain. Understanding the principles underlying the organisation of this system in the human brain, and whether these principles are reflected by available non-invasive in vivo neuroimaging… read more here.
Keywords: gabaa receptor; gabaergic neurotransmission; human brain; interneuron ... See more keywords
Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebral cortex"
DOI: 10.1093/cercor/bhab152
Abstract: Cortical interneurons (GABAergic cells) arise during embryogenesis primarily from the medial and caudal ganglionic eminences (MGE and CGE, respectively) with a small population generated from the preoptic area (POA). Progenitors from the lateral ganglionic eminence… read more here.
Keywords: islet1 precursors; isl1; precursors contribute; population ... See more keywords
Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.abm2545
Abstract: Parvalbumin-positive (PV+) interneurons play a critical role in maintaining circuit rhythm in the brain, and their reduction is implicated in autism spectrum disorders. Animal studies demonstrate that maternal immune activation (MIA) leads to reduced PV+… read more here.
Keywords: parvalbumin positive; microglial gpr56; maternal immune; interneuron ... See more keywords
Connectomic comparison of mouse and human cortex
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abo0924
Abstract: The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex of a mouse, but the possible differences in synaptic circuits between these species are still poorly understood. We used three-dimensional… read more here.
Keywords: network; microscopy; mouse; mouse human ... See more keywords
Multiple synaptic connections into a single cortical pyramidal cell or interneuron in the anterior cingulate cortex of adult mice
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Brain"
DOI: 10.1186/s13041-021-00793-8
Abstract: The ACC is an important brain area for the processing of pain-related information. Studies of synaptic connections within the ACC provide an understanding of basic cellular and molecular mechanisms for brain functions such as pain,… read more here.
Keywords: cell; pyramidal neurons; connections single; multiple synaptic ... See more keywords
Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2021.812905
Abstract: General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous group of specialized… read more here.
Keywords: narrative review; interneuron subtypes; relevance cortical; diversity ... See more keywords
Therapeutic Hypothermia Attenuates Cortical Interneuron Loss after Cerebral Ischemia in Near-Term Fetal Sheep
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043706
Abstract: Therapeutic hypothermia significantly improves outcomes after neonatal hypoxic-ischemic (HI) encephalopathy but is only partially protective. There is evidence that cortical inhibitory interneuron circuits are particularly vulnerable to HI and that loss of interneurons may be… read more here.
Keywords: near term; survival; interneuron; hypothermia ... See more keywords