Interoccasion variability in population pharmacokinetic models: identifiability, influence, interdependencies and derived study design recommendations
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DOI: 10.1007/s10928-025-09966-7
Abstract: Modeling interoccasion variability (IOV) of pharmacokinetic parameters is challenging in sparse study designs. We conducted a simulation study with stochastic simulation and estimation (SSE) to evaluate the influence of IOV (25, 75%CV) from numerous perspectives… read more here.
Keywords: population pharmacokinetic; interoccasion variability; variability; influence ... See more keywords