Reciprocal interplay between OTULIN–LUBAC determines genotoxic and inflammatory NF-κB signal responses
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DOI: 10.1073/pnas.2123097119
Abstract: Significance Deubiquitinases have emerged as a new class of modulators governing nuclear factor-kappa B (NF-κB) signaling. Ovarian tumor family deubiquitinase OTULIN inhibits NF-κB activation via counteracting the linear ubiquitin chain assembly complex (LUBAC). Clinically, OTULIN… read more here.
Keywords: otulin; reciprocal interplay; genotoxic inflammatory; interplay otulin ... See more keywords