Abstract A10: Exploring the interplay between the purinosome, a multienzyme, purine biosynthetic machine, and the Rheb-mTORC1 signaling axis
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DOI: 10.1158/1557-3125.pi3k-mtor18-a10
Abstract: Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleotides. We have previously… read more here.
Keywords: purine; rheb; interplay purinosome; purine biosynthetic ... See more keywords