Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens
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DOI: 10.1073/pnas.2220134120
Abstract: Significance Using combinatorial loss-of-function CRISPR screens, our study revealed a Bromo- and extra-terminal domain inhibitors (BETi) resistance network in KMT2A-r leukemia. Based on these findings, we have also revealed a corresponding synergy treatment regimen, significantly… read more here.
Keywords: inhibitor resistance; crispr screens; interrogating bromodomain; resistance ... See more keywords