Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.12.035
Abstract: The rapid replenishment of release-ready synaptic vesicles (SVs) at a limiting number of presynaptic release sites is required to sustain high-frequency neurotransmission in CNS neurons. Failure to clear release sites from previously exocytosed material has… read more here.
Keywords: snare; release sites; fast neurotransmission; neurotransmission ... See more keywords
Intersectin associates with synapsin and regulates its nanoscale localization and function
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1715341114
Abstract: Significance Mutations in genes regulating neurotransmission in the brain are implicated in neurological disorders and neurodegeneration. Synapsin is a crucial regulator of neurotransmission and allows synapses to maintain a large reserve pool of synaptic vesicles.… read more here.
Keywords: function; neurotransmission; intersectin; reserve pool ... See more keywords