Humans are animals, but are animals human enough? A systematic review and meta-analysis on interspecies differences in renal drug clearance.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.01.018
Abstract: Various animal models are used to study pharmacokinetics (PK) of drugs in development. Human renal clearance (CLr) should be predictable through interpolation from animal data by allometric scaling. Based on this premise, we quantified interspecies… read more here.
Keywords: drug clearance; drug; interspecies differences; clearance ... See more keywords
Deoxynivalenol and its modified forms: key enzymes, inter-individual and interspecies differences in metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2022.2088786
Abstract: Abstract Deoxynivalenol (DON) and its modified forms, including DON-3-glucoside (DON-3G), pose a major agricultural and food safety issue in the world. Their metabolites are relatively well-characterized; however, their metabolizing enzymes have not been fully explored.… read more here.
Keywords: metabolism; deoxynivalenol modified; modified forms; interspecies differences ... See more keywords