Long Interspersed Nuclear Elements 1 (LINE1): The chimeric transcript L1-MET and its involvement in cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2019.11.004
Abstract: Long interspersed nuclear elements 1 (LINE1) are non-LTR retrotransposons that represent the greatest remodeling force of the human genome during evolution. Genomically, LINE1 are constituted by a 5´ untranslated region (UTR), where the promoter regions… read more here.
Keywords: long interspersed; elements line1; line1 chimeric; nuclear elements ... See more keywords
The enhancer activity of long interspersed nuclear element derived microRNA 625 induced by NF-κB
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82735-x
Abstract: Transposable elements (TEs) are DNA sequences that cut or introduced into the genome, and they represent a massive portion of the human genome. TEs generate a considerable number of microRNAs (miRNAs) are derived from TEs… read more here.
Keywords: long interspersed; enhancer activity; binding sites; mirna 625 ... See more keywords
SINE_scan: an efficient tool to discover short interspersed nuclear elements (SINEs) in large-scale genomic datasets
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DOI: 10.1093/bioinformatics/btw718
Abstract: Motivation: Short Interspersed Nuclear Elements (SINEs) are transposable elements (TEs) that amplify through a copy‐and‐paste mode via RNA intermediates. The computational identification of new SINEs are challenging because of their weak structural signals and rapid… read more here.
Keywords: short interspersed; elements sines; nuclear elements; scan efficient ... See more keywords
The Transposable Element Environment of Human Genes Differs According to Their Duplication Status and Essentiality
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DOI: 10.1093/gbe/evab062
Abstract: Abstract Transposable elements (TEs) are major components of eukaryotic genomes and represent approximately 45% of the human genome. TEs can be important sources of novelty in genomes and there is increasing evidence that TEs contribute… read more here.
Keywords: duplication; nuclear elements; duplicated genes; interspersed nuclear ... See more keywords
Distribution, Diversity, and Long-Term Retention of Grass Short Interspersed Nuclear Elements (SINEs)
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evx145
Abstract: Abstract Instances of highly conserved plant short interspersed nuclear element (SINE) families and their enrichment near genes have been well documented, but little is known about the general patterns of such conservation and enrichment and… read more here.
Keywords: short interspersed; grass; interspersed nuclear; retention ... See more keywords
The differential expression of long interspersed nuclear elements‐1 as a marker for hypomethylation in Merkel cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.15265
Abstract: One side of the transparent film is adhesive, thus it can be used to cover the glass window and wrap the metal ring and the front of probe (Fig. 1a,b). The operator must ensure that… read more here.
Keywords: expression long; transparent film; interspersed nuclear; film ... See more keywords
Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.519206
Abstract: The retrotransposon long interspersed nuclear element-1 (LINE-1) can autonomously increase its copy number within a host genome through the retrotransposition process. LINE-1 is active in the germline and in neural progenitor cells, and its somatic… read more here.
Keywords: copy number; long interspersed; line; retrotransposition ... See more keywords
Exonization of a deep intronic long interspersed nuclear element in Becker muscular dystrophy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.979732
Abstract: The precise identification of pathogenic DMD variants is sometimes rather difficult, mainly due to complex structural variants (SVs) and deep intronic splice-altering variants. We performed genomic long-read whole DMD gene sequencing in a boy with… read more here.
Keywords: deep intronic; interspersed nuclear; becker muscular; long interspersed ... See more keywords
Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Atherosclerosis and Thrombosis"
DOI: 10.5551/jat.43570
Abstract: Aim: Aberrant global DNA methylation is involved in the development of several diseases, including cardiovascular disease (CVD). We investigated whether the methylation of long interspersed nuclear element-1 (LINE-1) in leukocytes is associated with dyslipidemia, a… read more here.
Keywords: methylation; long interspersed; dna; nuclear element ... See more keywords