Phenotype Transformation of Aortic Valve Interstitial Cells Due to Applied Shear Stresses Within a Microfluidic Chip
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-017-1871-z
Abstract: Despite valvular heart diseases constituting a significant medical problem, the acquisition of information describing their pathophysiology remains difficult. Due to valvular size, role and location within the body, there is a need for in vitro… read more here.
Keywords: phenotype transformation; interstitial cells; transformation aortic; transformation ... See more keywords
Tumor necrosis factor alpha and interleukin 1 beta suppress myofibroblast activation via nuclear factor kappa B signaling in 3D-cultured mitral valve interstitial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.03.075
Abstract: Mitral valve disease is a major cause of cardiovascular morbidity throughout the world. Many different mitral valve pathologies feature fibrotic remodeling, often accompanied by an inflammatory state. Mitral valve fibrosis is mediated by valvular interstitial… read more here.
Keywords: interstitial cells; mitral valve; myofibroblast; valve disease ... See more keywords
Substrate Chemistry and Morphology Influence the Valvular Interstitial Cells Mechanobiology
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2331
Abstract: Calcific Aortic Valve Disease (CAVD) is the most common form of valve disease in the Western world and represents a major healthcare burden. The primary driver for valvular calcification is the differentiation of valvular interstitial… read more here.
Keywords: valvular interstitial; interstitial cells; microscopy; chemistry ... See more keywords
Interstitial cells of Cajal are diminished in critically ill patients: Autopsy cases.
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition"
DOI: 10.1016/j.nut.2019.110591
Abstract: OBJECTIVE Gastrointestinal dysmotility in critically ill patients is important as enteral nutrition is crucial. However, normal gut motility is impaired under conditions of critical illness subsequent to severe insult. Interstitial cells of Cajal (ICC) form… read more here.
Keywords: interstitial cells; ill patients; cajal diminished; critically ill ... See more keywords
Mechanical strain induces a pro-fibrotic phenotype in human mitral valvular interstitial cells through RhoC/ROCK/MRTF-A and Erk1/2 signaling pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.08.008
Abstract: The mitral valve is a complex multilayered structure populated by fibroblast-like cells, valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold and are submitted to the mechanical deformations affecting valve at… read more here.
Keywords: mrtf; mechanical strain; valvular interstitial; rhoc rock ... See more keywords
Cardiac interstitial tetraploid cells can escape replicative senescence in rodents but not large mammals
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0453-z
Abstract: Cardiomyocyte ploidy has been described but remains obscure in cardiac interstitial cells. Ploidy of c-kit+ cardiac interstitial cells was assessed using confocal, karyotypic, and flow cytometric technique. Notable differences were found between rodent (rat, mouse)… read more here.
Keywords: escape replicative; interstitial cells; cardiac interstitial; cells escape ... See more keywords
Propulsive colonic contractions are mediated by inhibition-driven poststimulus responses that originate in interstitial cells of Cajal.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123020119
Abstract: SignificanceThe peristaltic reflex elicits colonic migrating motor complexes (CMMCs) that are thought to be generated by enteric excitatory neurons stimulating smooth muscle cells (SMCs). We found that atropine did not block CMMCs and present a… read more here.
Keywords: colonic contractions; interstitial cells; contractions mediated; propulsive colonic ... See more keywords
Immunofluorescence reveals unusual patterns of labelling for connexin43 localized to calbindin‐D28K‐positive interstitial cells in the pineal gland
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13578
Abstract: Gap junctions between cells in the pineal gland have been described ultrastructurally, but their connexin constituents have not been fully characterized. We used immunofluorescence in combination with markers of pineal cells to document the cellular… read more here.
Keywords: interstitial cells; calbindin d28k; cells pineal; immunofluorescence ... See more keywords
Myenteric networks of interstitial cells of Cajal are reduced in horses with inflammatory bowel disease.
Sign Up to like & getrecommendations! Published in 2019 at "Equine veterinary journal"
DOI: 10.1111/evj.13160
Abstract: BACKGROUND Inflammatory bowel disease (IBD) is a well-recognised but poorly understood disease complex in the horse. Clinical signs may vary but often include weight loss, diarrhoea and colic. The effect this disease process may have… read more here.
Keywords: bowel disease; interstitial cells; inflammatory bowel; myenteric networks ... See more keywords
Spatial relationship between telocytes, interstitial cells of Cajal and the enteric nervous system in the human ileum and colon
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15013
Abstract: Telocytes (TCs) are recently described interstitial cells, present in almost all human organs. Among many other functions, TCs regulate gastrointestinal motility together with the interstitial cells of Cajal (ICCs). TCs and ICCs have close localization… read more here.
Keywords: interstitial cells; microscopy; ileum colon; spatial relationship ... See more keywords
Long-Pulse Gastric Electrical Stimulation Repairs Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastric Antrum of Diabetic Rats
Sign Up to like & getrecommendations! Published in 2018 at "Gastroenterology Research and Practice"
DOI: 10.1155/2018/6309157
Abstract: Background/Aims The damage of interstitial cells of Cajal and smooth muscle cells has far-reaching implications in the pathogenesis of gastroparesis in diabetic patients. Gastric electrical stimulation (GES) is an efficient therapy for gastric motility disorders,… read more here.
Keywords: interstitial cells; muscle; group; muscle cells ... See more keywords