Interstitial Flow Promotes the Formation of Functional Microvascular Networks In Vitro through Upregulation of Matrix Metalloproteinase‐2
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202206767
Abstract: Self‐organized microvascular networks (MVNs) have become key to the development of many microphysiological models. However, the self‐organizing nature of this process combined with variations between types or batches of endothelial cells (ECs) often lead to… read more here.
Keywords: interstitial flow; upregulation matrix; matrix metalloproteinase; microvascular networks ... See more keywords
Extracellular Matrix-Derived Biophysical Cues Mediate Interstitial Flow-Induced Sprouting Angiogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c15180
Abstract: Sprouting angiogenesis is orchestrated by an intricate balance of biochemical and mechanical cues in the local tissue microenvironment. Interstitial flow has been established as a potent regulator of angiogenesis. Similarly, extracellular matrix (ECM) physical properties,… read more here.
Keywords: extracellular matrix; sprouting angiogenesis; collagen; flow ... See more keywords
Permeability and viscoelastic fracture of a model tumor under interstitial flow.
Sign Up to like & getrecommendations! Published in 2018 at "Soft matter"
DOI: 10.1039/c8sm00844b
Abstract: Interstitial flow in tumors is a key mechanism leading to cancer metastasis. Tumor growth is accompanied by the development of a leaky vasculature, which increases intratumoral pressure and generates an outward interstitial flow. This flow… read more here.
Keywords: interstitial flow; model tumor; pressure; tumor ... See more keywords
In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax4520
Abstract: Microenvironmental control of interstitial flow around pancreatic islets effectively maintains islet function in vitro. Native pancreatic islets interact with neighboring cells by establishing three-dimensional (3D) structures, and are surrounded by perfusion at an interstitial flow… read more here.
Keywords: perfusion; vivo mimicking; islet; islet spheroids ... See more keywords
Abstract A49: Tumor-associated interstitial flow promotes macrophage migration and pro-metastatic M2 phenotype in 3D ECM
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.epso16-a49
Abstract: The growth of solid tumor is often accompanied by an increase in the flow of interstitial fluid (interstitial flow) from the center of the tumor to the surrounding stroma. Recent studies have shown that elevated… read more here.
Keywords: macrophage migration; tumor associated; pro metastatic; interstitial flow ... See more keywords
A Transwell-Based Vascularized Model to Investigate the Effect of Interstitial Flow on Vasculogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9110668
Abstract: Interstitial flow plays a significant role in vascular system development, mainly including angiogenesis and vasculogenesis. However, compared to angiogenesis, the effect of interstitial flow on vasculogenesis is less explored. Current in vitro models for investigating… read more here.
Keywords: interstitial flow; flow vasculogenesis; effect interstitial; flow ... See more keywords