Facile preparation of model DNA interstrand cross-link repair intermediates using ribonucleotide-containing DNA.
Sign Up to like & getrecommendations! Published in 2022 at "DNA repair"
DOI: 10.1016/j.dnarep.2022.103286
Abstract: DNA interstrand cross-links (ICLs) are lesions with a covalent bond formed between DNA strands. ICLs are extremely toxic to cells because they prevent the separation of the two strands, which are necessary for the genetic… read more here.
Keywords: dna; dna interstrand; repair; repair intermediates ... See more keywords
Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "ACS nano"
DOI: 10.1021/acsnano.0c03781
Abstract: DNA alkylating agents generally kill tumor cells by covalently binding with DNA to form interstrand or intrastrand cross-links. However, in the case of cisplatin, only a few DNA adducts ( read more here.
Keywords: interstrand; dna; interstrand cross; cross ... See more keywords
Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10070
Abstract: DNA interstrand cross-links (ICLs) prevent DNA replication and transcription and can lead to potentially lethal events, such as cancer or bone marrow failure. ICLs are typically repaired by proteins within the Fanconi Anemia (FA) pathway,… read more here.
Keywords: cross links; dna; synthesis; dna duplexes ... See more keywords
Interstrand cross-linking implies contrasting structural consequences for DNA: insights from molecular dynamics
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DOI: 10.1093/nar/gkw1253
Abstract: Abstract Oxidatively-generated interstrand cross-links rank among the most deleterious DNA lesions. They originate from abasic sites, whose aldehyde group can form a covalent adduct after condensation with the exocyclic amino group of purines, sometimes with… read more here.
Keywords: molecular dynamics; dna; interstrand cross; cross ... See more keywords
The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11050585
Abstract: DNA interstrand cross-links (ICLs) represent a major barrier blocking DNA replication fork progression. ICL accumulation results in growth arrest and cell death—particularly in cell populations undergoing high replicative activity, such as cancer and leukemic cells.… read more here.
Keywords: dna interstrand; dna; fanc brca; interstrand cross ... See more keywords