Abstract IA12: Intra- and intertumoral heterogeneity and response to therapy in mouse models of SCLC
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DOI: 10.1158/1538-7445.mousemodels17-ia12
Abstract: Small cell lung cancer (SCLC) is a high-grade neuroendocrine carcinoma that accounts for ~15% of all lung cancers and causes over 200,000 deaths worldwide each year. The majority of SCLC patients have metastatic disease at… read more here.
Keywords: models sclc; intertumoral heterogeneity; mouse models; mouse ... See more keywords
Different Originating Cells Underlie Intertumoral Heterogeneity in Lung Neuroendocrine Tumors.
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DOI: 10.1158/2159-8290.cd-18-0979
Abstract: Studies in genetically engineered mouse models of neuroendocrine lung cancer suggest that differences in cells of origin underlie subtype variations in this class of cancers. These findings highlight the concept that the same driver mutations… read more here.
Keywords: different originating; originating cells; underlie intertumoral; lung ... See more keywords
Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model
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DOI: 10.3390/cancers13102293
Abstract: Simple Summary Metastatic melanoma patients may present with multiple, simultaneous metastases that are genetically different. This intertumoral heterogeneity can cause these tumors to respond differently to the same systemic therapy. Progression of any one tumor,… read more here.
Keywords: melanoma; heterogeneity; novel murine; synchronous melanoma ... See more keywords