Randomized, Blinded, Placebo‐ and Positive‐Controlled Crossover Study to Determine the Effect of Deferiprone on the QTc Interval in Healthy Subjects
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DOI: 10.1002/cpdd.352
Abstract: This study evaluated whether deferiprone, an oral iron chelator, acts to prolong the QT interval. Fifty healthy volunteers received single doses of each of the following: therapeutic dose of deferiprone (33 mg/kg), supratherapeutic dose (50… read more here.
Keywords: qtc interval; deferiprone; study; effect ... See more keywords
Evaluation of the Potential Effect of Iptakalim Hydrochloride on the QT Interval in Single‐ and Multiple‐Ascending‐Dose Studies Using Concentration‐QTc Analysis
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DOI: 10.1002/cpdd.945
Abstract: Cardiotoxicity has been one of the most common causes of withdrawal of drugs from the market, and prolongation of the QT interval is one of the manifestations of drug cardiotoxicity. Iptakalim hydrochloride (ITKL) is a… read more here.
Keywords: effect; interval; iptakalim hydrochloride; concentration ... See more keywords
Correlation between frontal QRS‐T angle, Tp‐e interval, and Tp‐e/QT ratio to coronary artery severity assessed with SYNTAX score in stable coronary artery disease patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Arrhythmia"
DOI: 10.1002/joa3.12756
Abstract: It is known that a wide frontal QRS‐T(f[QRS‐T]) angle in the electrocardiography (ECG) is associated with poor cardiovascular outcomes. The Tp‐e (the interval from the peak to the end of the T wave) interval and… read more here.
Keywords: syntax; interval; ratio; qrs ... See more keywords
RIMeta: An R shiny tool for estimating the reference interval from a meta‐analysis
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DOI: 10.1002/jrsm.1626
Abstract: A reference interval, or an interval in which a prespecified proportion of measurements from a healthy population are expected to fall, is used to determine whether a person's measurement is typical of a healthy individual.… read more here.
Keywords: meta analysis; reference; interval; shiny tool ... See more keywords
Determining the optimal radiation‐surgery interval (RSI) for oncologic proctectomy following radiotherapy for rectal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.27273
Abstract: Preoperative radiotherapy has improved outcomes in rectal cancer patients, however, the optimal interval between radiation and proctectomy is unknown. A review of contemporary literature suggests an 8–12 week interval between radiation and surgery likely improves… read more here.
Keywords: radiotherapy; interval; radiation; radiation surgery ... See more keywords
Setting the beat of an internal clock: Effects of dexamphetamine on different interval ranges of temporal processing in healthy volunteers
Sign Up to like & getrecommendations! Published in 2019 at "PsyCh Journal"
DOI: 10.1002/pchj.274
Abstract: Drug studies are powerful models to investigate the neuropharmacological mechanisms underlying temporal processing in humans. This study administered dexamphetamine to 24 healthy volunteers to investigate time perception at different time scales, along with contributions from… read more here.
Keywords: time; healthy volunteers; working memory; interval ... See more keywords
Duration of the patient interval in breast cancer and factors associated with longer delays in low‐and middle‐income countries: A systematic review with meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Psycho-Oncology"
DOI: 10.1002/pon.6064
Abstract: Breast cancer survival is lower in low‐ and middle‐income countries (LMICs) partially due to many women being diagnosed with late‐stage disease. The patient interval refers to the time elapsed between the detection of symptoms and… read more here.
Keywords: interval; breast cancer; income countries; patient interval ... See more keywords
Relevance of the antenatal corticosteroids-to-delivery interval in the prevention of neonatal respiratory distress syndrome through the eyes of causal inference: a review and target trial
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DOI: 10.1007/s00404-021-06213-5
Abstract: To critically analyse the literature on the antenatal corticosteroids (ACS)-to-birth interval from a causal point of view and to present a solution to the problem of bias caused by post hoc analysis. Due to the… read more here.
Keywords: trial; target trial; acs birth; interval ... See more keywords
Three-year interval for endoscopic screening may reduce the mortality in patients with gastric cancer
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DOI: 10.1007/s00464-018-6353-3
Abstract: BackgroundEndoscopic screening has been adopted in South Korea for the national screening of gastric cancer (GC). This study aimed to assess the effect on overall survival of GC patients and determine the optimal endoscopic screening… read more here.
Keywords: gastric cancer; may reduce; group; endoscopic screening ... See more keywords
An approach for solving a fuzzy bilevel programming problem through nearest interval approximation approach and KKT optimality conditions
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DOI: 10.1007/s00500-016-2144-8
Abstract: In this paper, we consider a kind of bilevel linear programming problem where the coefficients of both objective functions are fuzzy numbers. In order to deal with such a problem, the original problem can be… read more here.
Keywords: programming problem; interval; bilevel programming; approach ... See more keywords
Factors impacting time to diagnosis in pediatric CNS tumors in Chinese children
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DOI: 10.1007/s00520-020-05863-6
Abstract: This study aimed to investigate the factors impacting time to diagnosis in pediatric central nervous system tumors. A descriptive, cross-sectional design was used in this study. A self-developed questionnaire for health-seeking behavior and influencing factors… read more here.
Keywords: impacting time; time; time diagnosis; interval ... See more keywords