STEIN: A simple toxicity and efficacy interval design for seamless phase I/II clinical trials.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7428
Abstract: Seamless phase I/II dose-finding trials are attracting increasing attention nowadays in early-phase drug development for oncology. Most existing phase I/II dose-finding methods use sophisticated yet untestable models to quantify dose-toxicity and dose-efficacy relationships, which always… read more here.
Keywords: toxicity; phase; interval design; dose finding ... See more keywords